Hans Gregersen, Ph.D. 

Professor
La Jolla Bioengineering Institute
La Jolla, CA
email

  

 

 

 

EDUCATION

1999

MPM

University of Odense, Denmark

Strategic Management
1994 Ph.D.

University of Aarhus, Denmark

Health Science
1988 M.D.

University of Aarhus, Denmark

Medicine

EXPERIENCE  

2004-present

Professor, La Jolla Bioengineering Institute, La Jolla, CA

2001-2004

Professor at Haukeland University Hospital, Bergen, Norway.

1999-2004

Professor. Center for Sensory-Motor Interaction, Aalborg University, Denmark

1996-1999

Associate professor. Clinical Research Institute. Aarhus University
1994-1996 Visiting Professor. Institute of Mechanics and Materials Bioengineering Institute, UC San Diego.
1993-1994 Assistant professor. Clinical Research Institute. Aarhus University.
1988-1992 Research fellow. Clinical Research Institute. Aarhus University.
1986-1988 Research scholarship. Clinical Research Institute. Aarhus University, Denmark.

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS  

2004-2006

Editorial board member. World Journal of Gastroenterology

2003-2005

The board of the Clinical Institute. Aarhus University.
2003-2004 Faculty for the European Neurogastroenterology Summer School
2003-Present Board member on the Danish Medical Board Foundation
2003 Director. Center of Visceral Biomechanics and Pain (virtual center based in Aalborg and La Jolla, Ca)
2001-Present Research Director and Chairman of the Research Council, Aalborg Hospital.
1998 Evaluation Committee for promotion to associate research bioengineering. UC San Diego.
1998-2002 Faculty member of the Scandinavian Postgraduate course on GI Motility.
1997-1998 Board member of the Danish Biomedical Engineering Society.
1996-Present Served on 8 committees as opponent on Ph.D.- theses and Dr.medical science theses.
1992-Present Supervised 22 Ph.D. students at Danish, Norwegian, British and Irish universities.

HONORS

2004

International Health Professional of the Year. Nominated by the International Biographical Centre, Cambridge, England

1999-2002 

Advisory Professor. Chongqing University, Chongquing, China.

1999-2002 

Advisory Professor. The Polytechnic University of Beijing. Beijing, China.

1997

American Clinical Gastroenterology Research Award (with Dr. Rao on Fecal Incontinence  project).

1992

Astra’s Travel Award for Gastroenterologists.
1992 Nordic Gastroenterology Research Award. Smith, Kline & Beecham.
1992 Nordic Gastroenterology Research Award. Smith, Kline & French.
1978 Award in Philips International Competition for young researchers and inventors.
1977 Award in Philips International Competition for young researchers and inventors.

 

SELECTED PUBLICATIONS  

  1. Tanko LB, Simonsen U, Frøbert O, Gregersen H, Bagger JP, Mikkelsen EO. Vascular reactivity to nifedipine and Ca++ in vitro. The role of preactivation, wall tension and geometry. Eur J Pharmacol 2000;387:305-14.

  2. Gregersen H. Development of a tensostat for gastric perception studies. Gastroenterology 2000;118:641-3.

  3. Andersen NT, Hobolth A, Gregersen H, Væth M. Implicitly defined non-linear models of elastic properties of organs. Department of Biostatistics, University of Aarhus, Denmark. Research Report 2000-4, August 2000.

  4. Gregersen H. Residual strain in the gastrointestinal tract: a new concept. Neurogastroenterol Motil 2000;12:411-4.

  5. Gao C, Zhao J, Gregersen H. Histomorphometry and strain distribution in pig duodenum with reference to the zero-stress state. Dig Dis Sci 2000;45:15000-8.

  6. Zhao J, Lu X, Zhuang F, Gregersen H. Biomechanical and morphometric properties of the arterial wall referenced to the zero-stress state in experimental diabetes. Biorheology 2000;37:385-400.

  7. Gregersen H, Kassab GS, Fung YC. The zero-stress state of the gastrointestinal tract: Biomechanical and functional implications. Dig Dis Sci 2000;45:2271-81.

  8. Jørgensen CS, Ahrensberg JM, Gregersen H, Flyvberg A. Tension-strain relations and morphometry of the rat small intestine in experimental diabetes. Dig Dis Sci 2001;46:960-7.

  9. Villadsen GE, Storkholm JH, Zachariae H, Hendel L, Bendtsen F, Gregersen H. Esophageal pressure-cross-sectional area distributions and secondary peristalsis in relation to subclassification of systemic sclerosis. Neurogastroenterol Motil 2001;13:199-210.

  10. Assentoft JE, Gregersen H, O’Brien Jr. WD. Propagation speed of sound assessment in the layers of the guinea-pig esophagus by means of acoustic microscopy. Ultrasonics 2001;39:263-8.

  11. Dou Y, Gregersen S, Zhao J, Zhuang F, Gregersen H. Effect of re-feeding after starvation on biomechanical properties in rat small intestine. J Med Eng Phys 2001;23:557-66.

  12. Gregersen H, Weis S, McCulloch AD. Esophageal morphometry and residual strain in a mouse model of osteogenesis imperfecta. Neurogastroenterol Motil 2001;13:457-64.

  13. Jørgensen CS, Assentoft JE, Knauss D, Gregersen H, Briggs A. Small intestinal wall distribution of elastic stiffness measured with 500 MHz scanning acoustic microscopy. Ann Biomech Eng 2001;29:1059-63.

  14. Zhao J, Day J, Zhuang FY, Gregersen H. Regional arterial stress-strain distributions referenced to the zero-stress state in the rat. Am J Physiol 2002;282:H622-H629.

  15. Duch BU, Andersen HL, Smith J, Kassab GS, Gregersen H. Structural and mechanical remodeling of the common bile duct after obstruction. Neurogastroenterol Motil 2002;14:1-12.

  16. Dou Y, Lu X, Zhao J, Gregersen H. Morphometric and biomechanical remodeling in the intestine after small bowel resection in the rat. Neurogastroenterol Motil 2002;14:43-53.

  17. Krogh K, Mosdal C, Gregersen H, Laurberg S. Rectal wall properties in patients with acute and chronic spinal cord lesions. Dis Colon Rectum 2002;45:641-9.

  18. Dou Y, Gregersen S, Zhao J, Zhuang FY, Gregersen H. Morphometric and biomechanical intestinal remodeling induced by fasting in rats. Dig Dis Sci 2002;47:1158-68.

  19. Barlow JD, Gregersen H, Thompson DG. Identification of biomechanical factors associated with the perception of distension in the human oesophagus. Am J Physiol  2002;282:G683-G689.

  20. Zhao J, Sha H, Zhuang FY, Gregersen H. Morphological properties and residual strain along the small intestine in the rat. World J Gastroenterol 2002;8:312-7.

  21. Drewes AM, Schipper K-P, Dimcevski G, Petersen P, Andersen OK, Gregersen H, Arendt-Nielsen L. Multimodal assessment of pain in the esophagus – a new experimental model. Am J Physiol Gastrointest Liver Physiol 2002;283:G95-G103. 

  22. Gregersen H, Gilja OH, Hausken T, Heimdal A, Gao C, Matre K, Ødegaard S, Berstad A. Biomechanical wall properties in the human gastric antrum using B-mode ultrasonography and volume-controlled antral distension.  Am J Physiol 2002;283:G368-G375.

  23. Gao C, Petersen P, Liu W, Arendt-Nielsen L, Drewes AM, Gregersen H. Sensory-motor responses to volume-controlled duodenal distension Neurogastroenterol Motil 2002;14:365-74.

  24. Yang J, Vinter-Jensen L, Zhuang FY, Gregersen H. The morphometry and biomechanical properties of the rat small intestine after systemic treatment with epidermal growth factor in rats. Biorheology 2002;39:719-733.

  25. Gilja OH, Heimdal A, Hausken T, Gregersen H, Matre K, Berstad A, Ødegaard S. Strain during gastric contractions can be measured using Doppler ultrasonography. Ultrasound Med Biol. 2002 Nov-Dec;28(11-12):1457-65.

  26. Kassab GS, Gregersen H, Nielsen SL, Lu X, Tanko LB, Falk E. Remodeling of the LAD descending artery in a porcine model of supravalvular aortic stenosis. J Hypertens 2002;20:2429-37.

  27. Zhao J, Sha H, Zhou S, Tong X, Zhuang FY, Gregersen H. Remodeling of the zero-stress state of the small intestine in STZ-induced diabetic rats. Dig Liv Dis 2002 Oct;34(10):707-16.      

  28. Gao C, Arendt-Nielsen L, Liu W, Petersen P, Drewes AM, Gregersen H. Sensory and biomechanical responses to ramp-controlled distension of the human duodenum. Am J Physiol Gastrointest Liver Physiol 2003;284(3):G461-71.

  29. Pedersen J, Gao C, Egekvist H, Bjerring P, Arendt-Nielsen L, Gregersen H, Drewes AM. Pain and biomechanical responses to distention of the duodenum in patients with systemic sclerosis. Gastroenterology. 2003;124(5):1230-9.

  30. Liao D, Yang J, Zhao J, Zeng Y, Vinter-Jensen L, Gregersen H. The effect of epidermal growth factor on the incremental Young's moduli in the rat small intestine. Med Eng Phys. 2003;25(5):413-8.

  31. Drewes AM, Pedersen J, Liu W, Arendt-Nielsen L, Gregersen H. Controlled mechanical distension of the human oesophagus: sensory and biomechanical findings. Scand J Gastroenterol. 2003;38(1):27-35.

  32. Dang Q, Gregersen H, Duch B, Kassab GS. Indicial Response Functions of Growth and Remodeling of Bile Duct Post Obstruction. Am J Physiol Gastrointest Liver Physiol. 2004; 286 (3):G420-7.

  33. Yang J, Zhao J, Zeng Y, Gregersen H. Biomechanical properties of the rat oesophagus in experimental type-1 diabetes. Neurogastroenterol Motil. 2004; 16 (2):195-203.

  34. Liao D, Duch BU, Stødkilde-Jørgensen H, Zeng YJ, Gregersen H, Kassab GS. Tension and Stress Calculations in a 3-D Fourier Model of Gall Bladder Geometry obtained from MR Images. Ann Biomed Eng. 2004; 32 (5):744-55.

  35. Liao D, Gregersen H, Hausken T, Gilja OH, Mundt M, Kassab GS. Analysis of surface geometry of the human stomach using real-time 3D ultrasonography in vivo. Neurogastroenterology and Motility. 2004; 16:315-324. 

  36. Yu J, Zeng Y, Zhao J, Liao D, Gregersen H. Quantitative Analysis of Collagen Fiber Angle in the Submucosa of Small Intestine. Comput Biol Med. 2004; 34(6):539-50.

  37. Gregersen H, Lu X, Zhao J. Physiological growth is associated with esophageal morphometric and biomechanical changes in rats. Neurogastroenterol Motil. 2004; 16:403-412.

  38. Liao D, Zhao J, Fan Y, Gregersen H. Two-layered quasi-3D finite element model of the oesophagus. Med Eng Phys 2004; 26:535-543.

  39. Zeng Y, Yang J, Zhao J, Liao D, Zhang E, Gregersen H, Xu X, Xu H, Xu C. Morphologic and biomechanical changes of rat oesophagus in experimental diabetes. World J Gastroenterol. 2004; 10 (17):2519-2523.

  40. Li ZJ, Huang W, Jiang Z, Gregersen H, Fung YC. Tissue remodeling of rat pulmonary arteries in recovery from hypoxic hypertension. Proceedings of the National Academy of Science. 2004; 101(31):11488-93.

  41. Zeng YJ, Qiao YH, Yang J, Gregersen H, Zhang EP, Hu XH, Hu H. Torque properties of the rat oesophagus for physiological and diabetic conditions. Physiological Measurement 2004;25:1211-1221.

  42. Gao C, Petersen J, Arendt-Nielsen L, Drewes AM, Gregersen H. Age-related variation in mechanical and sensory function of the human duodenum. J Applied Research 2004; 4 (1):99-110.

  43. Liao D, Gao S, Zeng Y, Liu Y, Yang J, Zhao J, Vinter-jensen L, Gregersen H. The incremental Young’s moduli in the rat small intestine caused by epidermal growth factor. Acta Mechanical Sinica 2004;36:171-176.

  44. Yang J, Liao D, Zhao J, Gregersen H. Shear modulus of elasticity of the esophagus. Ann Biomed Eng 2004;32:1223-30.

  45. Gregersen H, Kassab GS, Fung YC. Determination of membrane tension during balloon distension of intestine. Mechanics and Biochemistry of Biosystems 2004;1:191-200.

  46. McMahon B, Frøkjær JB, Drewes AM, Gregersen H. A new measurement of oesophago-gastric junction competence. Neurogastroenterol Motility 2004;16:543-6.

  47. Lu X, Zhao J, Gregersen H. Small intestinal morphometric and biomechanical remodeling during physiological growth in rats. J Biomech. 2005;38:417-26.

  48. Liao D, Zhao J, Gregersen H. Regional surface geometry of the rat stomach based on three dimensional curvature analysis. Phys Med Biol 2005;50:231-246.

BOOKS

  1. Jensen SL, Gregersen H, Amiri MS, Moody FM (eds.): Essentials of Experimental Surgery. Gastroenterology. Harwood Academic Publishers. 57 chapters, 800 pages. Published March 1996.

  2. Gregersen H. Biomechanics of the Gastrointestinal Tract. Springer-Verlag. Published in 2002.

  3. Ødegaard S, Gilja OH, Gregersen H. Basic and New Aspects of Gastrointestinal Ultrasonography. World Scientific Publishers. 2005. ISBN 981-238-845-1. 

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