Mirianas Chachisvilis, Ph.D. 
Associate Professor
La Jolla Bioengineering Institute
La Jolla, California 
email

  

 

 

 

EDUCATION

Lund University
Lund Sweden		 Ph.D. 1996 Chemical Physics
Vilnius University
Vilnius, Lithuania		 M.S. 1988 Physics

EXPERIENCE 

2008 - Present Associate Professor
La Jolla Bioengineering Institute
La Jolla, CA

2004 - 2008

Assistant Professor
La Jolla Bioengineering Institute
La Jolla, CA

2001 – 2004

Senior Staff Scientist 
Genoptix, Inc.
San Diego, CA

2000 – 2001

Research Assistant Professor
Department  of  Chemical  Physics
Lund University, Sweden

1997 – 2000

Postdoctoral  Scholar
Arthur Amos Noyes Laboratory of Chemical Physics and Laboratory  for  Molecular  Sciences
California Institute of Technology.

1994 – 1996

Graduate Research Assistant
Department  of  Chemical  Physics
Lund University, Sweden
1993 – 1994 Graduate Research Assistant
Department of Physical Chemistry
Umeå University, Sweden
1988 – 1992 Research Assistant
Institute of Physics - Academy of Sciences
Vilnius, Lithuania
1986 – 1988 Research Assistant
Physics Department - Vilnius University
Vilnius, Lithuania

TEACHING  

2003 - 2005 University California San Diego
Lectures on light scattering in biology for bioengineering class
2001 Lund Laser Center
Graduate Course on applications of lasers to spectroscopy within Lund Laser Center
2000 Lund University
Graduate course on Photochemistry and Spectroscopy
1996 Series of lectures for junior graduate students on various methods and techniques of time resolved femtosecond spectroscopy

HONORS AND MEMBERSHIPS  

2002 – present American Association for the Advancement of Science
1999 Four year research grant from Swedish Natural Science Research Council
1999 Wilhelm Faxes prize awarded by Lund University.
1998 – present American Chemical Society
1998 Invitation to chair a session on the chemical reaction dynamics in condensed phase in  XIII  Informal  Conference  on Photochemistry, Pasadena, CA.
1997 Prize for best Ph.D. thesis in chemistry in Sweden awarded jointly by The Swedish  Chemical  Society  (Kemistsamfundet) and The Swedish Association of Scientists (Sveriges Naturvetareförbund)
1996 A  three year  postdoctoral  fellowship from  The Swedish Foundation for International Cooperation in Research and Higher Education

PUBLICATIONS:  

  1. M. Chachisvilis, Y.-L. Zhang, J.A. Frangos, G Protein-coupled Receptors Sense Fluid Shear Stress in Endothelial Cells, Proc. Natl. Acad. Sci. USA, 103 (2006) 15463-15468. [Full Text]  (See also highlights by J. Pickett, Even Receptors get stressed, Nature Reviews Molecular and Cell Biology, 7 (2006) 880 [Full Text]; and by R.P. Kruger, Stress Prods a GPCR in Action, Cell 127 (2006) 655). [Full Text] 

  2. Y-L. Zhang, J.A. Frangos, and M. Chachisvilis, Laurdan Fluorescence Senses Mechanical Strain in the Lipid Bilayer Membrane, Biochem.  Biophys. Res. Commun. 347 (2006) 838-841.  [Full Text]

  3. B. Shao, J.S. Jaffe, M. Chachisvilis and S.C. Esener, Angular resolved light scattering for discriminating among marine picoplankton: modeling and experimental measurements, Optics Express 14 (2006) 12473.  [Full Text]

  4. R.A. Flynn, B. Shao, M. Chachisvilis, M. Ozkan, S.C. Esener, Counter-propagating optical trapping system for size and refractive index measurement of microparticles, Biosensors & Bioelectronics 21 (2006) 1029-1036.  [Full Text]

  5. R.A. Flynn, B. Shao, M. Chachisvilis, M. Ozkan, S.C. Esener, Two-beam optical traps: Refractive index and size measurements of microscale objects, Biomedical Microdevices 7 (2005) 93-97.[Full Text]

  6. D. Watson, N.D. Hagen, J. Diver, P. Marchand, and M. Chachisvilis, Elastic light scattering from single cells: orientational dynamics in optical trap, Biophysical Journal  87 (2004) 1 [Full Text]

  7. A. H. Forster, M. M. Wang, W. F. Butler, M. Chachisvilis, T. D.Y. Chung, Sadik C. Esener, J. M. Hall, O. Kibar, K. Lykstad, P. J. Marchand, E. M. Mercer, L. M. Pestana, S. Sur, E. Tu, R. Yang, H. Zhang, and I. Kariv, Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model, Analytical Biochemistry 327 (2004) 14 [Full Text]

  8. H. Zhang, E. Tu, N. D. Hagen, C. A. Schnabel, M. J. Paliotti, W. S. Hoo, P. M. Nguyen, J. R. Kohrumel, W. F. Butler, M. Chachisvilis, and P. J. Marchand, Time-of-Flight Optophoresis Analysis of Live Whole Cells in Microfluidic Channels, Biomedical Microdevices, 6 (2004) 11.   [Full Text]

  9. M. M.-L. Grage, Y. Zaushitsyn, A. Yartsev, M. Chachisvilis, V. Sundström, and T. Pullerits, Ultrafast excitation energy transfer and trapping in a thin polymer film, Phys. Review. B 67 (2003) 205207 [Full Text]

  10. M. M. Wang, C.A. Schnabel, M. Chachisvilis, R. Yang, M. J. Palioti, L. A. Simons, L. McMullin, N. Hagen, K. Lykstad, E. Tu, L. M. Pestana, S. Sur, H. Zhang, W. F. Butler, I. Kariv, and P. J. Marchand, Optical forces for noninvasive cellular analysis, Applied Optics, 42 (2003) 5765  [Full Text]

  11. M. Chachisvilis, A.H. Zewail, Femtosecond dynamics of pyridine in the condensed phase: valence isomerization by conical intersections, J. Phys. Chem. A 103 (1999) 7408. [Full Text]

  12. T. Fiebig, M. Chachisvilis, M.M. Manger, A. Douhal, I. Garcia-Ochoa, A. de La Hoz Ayuzo, A.H. Zewail, Femtosecond dynamics of double proton transfer in a model DNA base pair: 7-Azaindole dimers in the condensed phase, J. Phys. Chem. A 103 (1999) 7419. [Full Text]

  13. A. Douhal, T. Fiebig, M. Chachisvilis, A.H. Zewail, Femtochemistry in nanocavities: Reactions in cyclodextrins, J. Phys. Chem. A 102 (1998) 1657. [Full Text]

  14. M. Chachisvilis, I. Garcia-Ochoa, A. Douhal, A.H. Zewail, Femtochemistry in nanocavities: dissociation, recombination and vibrational cooling of iodine in cyclodextrin, Chem. Phys. Lett. 293 (1998) 153. [Full Text]

  15. M. Chachisvilis, T. Fiebig, A. Douhal, A.H. Zewail, Femtosecond dynamics of a hydrogen-bonded model base pair in the condensed phase: Double proton transfer in 7-azaindole, J. Phys. Chem. A 102 (1998) 669.  [Full Text]

  16. J.S. Baskin, M. Chachisvilis, M. Gupta, A.H. Zewail, Femtosecond dynamics of solvation: Microscopic friction and coherent motion in dense fluids, J. Phys. Chem. A 102 (1998) 4158.  [Full Text]

  17. S. Jursenas, A. Gruodis, G. Kodis, M. Chachisvilis, V. Gulbinas, E.A. Silinsh, Free and self-trapped charge-transfer excitons in crystals of dipolar molecules of  N,N-dimethylaminobenzylidene 1,3-indandione, J. Phys. Chem. B 102 (1998) 1086. [Full Text]

  18. J.S. Baskin, M. Gupta, M. Chachisvilis, A.H. Zewail, Femtosecond dynamics of microscopic friction: nature of coherent versus diffusive motion from gas to liquid density, Chem. Phys. Lett. 275 (1997) 437.  [Full Text]

  19. M. Chachisvilis, O. Kuhn, T. Pullerits, V. Sundström, Excitons in photosynthetic purple bacteria: Wavelike motion or incoherent hopping? J. Phys. Chem. B 101 (1997) 7275. [Full Text]

  20. M. Chachisvilis and V. Sundström, Femtosecond vibrational dynamics and relaxation in the core light‑harvesting complex of photosynthetic purple bacteria, Chem. Phys. Lett. 261 (1996) 165.  [Full Text]

  21. M. Chachisvilis, V. Chervony, A. Shulga, B. Källebring, S. Larsson and V. Sundström, Spectral and Photophysical Properties of Ethylene-Bridged Side-to-Side Porphyrin Dimers. I. Ground State Absorption and Fluorescence Study and Calculation of Electronic Structure of tbis=OEP [trans-1,2-bis(meso-octaethylporphyrinyl)ethene], J. Phys. Chem. 100 (1996) 13857.  [Full Text]

  22. M. Chachisvilis, V. Chervony, A. Shulga, B. Källebring, S. Larsson and V. Sundström, Spectral and Photophysical Properties of Ethylene-Bridged Side-to-Side Porphyrin Dimers. II. Femtosecond Transient Absorption and Picosecond Fluorescence Study of tbis=OEP {trans-1,2-bis(meso-octaethylporphyrinyl)ethene}, J. Phys. Chem. 100 (1996) 13867.  [Full Text]

  23. T. Pullerits, M. Chachisvilis, and V. Sundström, Exciton delocalization length in the B850 antenna of Rhodobacter Sphaeroides, J. Phys. Chem. 100 (1996) 10787.  [Full Text]

  24. M. Chachisvilis and V. Sundström,  The tunneling contributions to optical coherence in femtosecond pump-probe spectroscopy of a three level system. J. Chem. Phys. 104, (1996) 5734.  

  25. V. Gulbinas, M. Chachisvilis, L. Valkunas and V. Sundström, Excited state dynamics of phthalocyanine films.  J. Phys. Chem. 100 (1996) 2213.  [Full Text]

  26. S. Hess, M. Chachisvilis, K. Timpmann, M.R. Jones, G.J. Fowler, C.N. Hunter and V. Sundström,  Temporally and spectrally resolved subpicosecond energy transfer within the peripheral antenna complex (LH2) and from LH2 to the core antenna complex in photosynthetic purple bacteria.  Proc. Natl. Acad. Sci. USA, 92 (1995) 12333.  [Full Text]

  27. M. Chachisvilis, H. Fidder, T. Pullerits, and V. Sundström,  Coherent nuclear motions in light-harvesting pigments and dye molecules, probed by ultrafast spectroscopy. J. of Raman Spectroscopy,  26 (1995) 513.  [Full Text]

  28. M. Chachisvilis, H. Fidder and V. Sundström,   Electronic coherence in pseudo two-colour pump-probe spectroscopy,  Chem. Phys. Lett.  234 (1995) 141. [Full Text]

  29. T. Pullerits, M. Chachisvilis, I. Fedchenia, M.R. Jones, C.N. Hunter, S. Larsson and V. Sundström, Coherent versus incoherent energy transfer in the light harvesting complexes of photosynthetic bactria, Lithuanian J. of Physics, 34 (1994) 329.

  30. V. Gulbinas, M. Chachisvilis, A. Persson, S. Svanberg and V. Sundström, Ultrafast excitation relaxation in colloidal particles of chloroaluminum phthalocyanine: one-dimensional exciton-exciton anihilation. J. Phys. Chem. 98 (1994) 8118. [Full Text]

  31. T. Pullerits, M. Chachisvilis, M.R. Jones, C.N. Hunter, and V. Sundström, Exciton dynamics in the light-harvesting complexes of Rhodobacter sphaeroides. Chem. Phys. Lett. 224 (1994) 355.  [Full Text]

  32. M. Chachisvilis, T. Pullerits, M.R. Jones, C.N. Hunter, and V. Sundström,  Vibrational dynamics in the light-harvesting complexes of the photosynthetic bacterium Rhodobacter sphaeroides. Chem. Phys. Lett. 224  (1994) 345.  [Full Text]

  33. V. Kopp, I. Mochalov, A. Mikhailov and M. Chachisvilis, Interference of two-photon and Raman resonances in KGd (WO4)2 Nd3+ crystals. Sov. Optics and Spectroscopy, 5 (1991) 950.

  34. V. Ivaska, M. Zilinskas and M. Chachisvilis, Investigation of magnetic field   distribution in the transition: superconductor-ferromagnetic. Lithuanian J. of Phys.  3 (1989) 310.

CONFERENCE PAPERS:

  1. S. Hess, M. Chachisvilis, T. Pullerits, M.R. Jones, G.J.C. Fowler, C.N. Hunter and  V.Sundström, Localized and delocalized excitations in photosynthetic antenna, Femtochemistry: Ultrafast Chemical and Physical Processes in Molecular Systems, Lausanne, 1995 (World Scientific, Singapore, 1996).

  2. T. Pullerits, M. Chachisvilis, and V. Sundström,  Exciton dynamics and delocalization length in B850 molecules of LH2 of Rhodobacter Sphaeroides. in Photosynthesis: from Light to Biosphere, Proccedings of the Xth Inter, Photosynthesis Congress, Montpeler 1995.  Vol. 1 (1995), 107-114.

  3. S. Hess, M. Chachisvilis, T. Pullerits, M.R. Jones, G.J.C. Fowler, C.N. Hunter and V. Sundström, Localized excitations in photsynthesis. LH2 - a testing ground of energy transfer. in Photysthesis: from Light to Biosphere, Proccedings of the Xth Inter, Photosynthesis Congress, Montpeler 1995.  Vol. 1 (1995) 119-122.

  4. M. Chachisvilis and V. Sundström, The tunneling contributions in the pump-probe spectroscopy of the three level system, Femtochemistry: Ultrafast Chemical and Physical Processes in Molecular Systems, Lausanne, 1995 (World Scientific, Singapore, 1996).

  5. M. Chachisvilis, T. Pullerits, M.R. Jones, C.N. Hunter and V .Sundström,  Coherent nuclear motions and exciton state dynamics photosynthetic light-harvesting pigments. In Ultrafast Phenomena, 1994.

  6. P.J. Marchand, M.M. Wang, A.H. Forster, W.F.Butler, M.Chachisvilis, J.M. Hall, and I. Kariv, "Drug response measurements using optical forces," Proc. OSA Optics in Computing OC'2003, Washington, DC, June 2003.

  7. P. J. Marchand, M. Wang, C. Schnabel, M. Chachisvillis, H. Zhang, R. Yang, L. McMullin, N. Hagen, O. Kibar, S. Esener, G. Tu, S. Sur, L. Pestana, K. Haden, K. Truong, W. Seto, K. Lykstad, L. Simons, M. Paliotti, I. Kariv, J. Hall, and W. Butler, "Cellular analysis based on moving infrared optical gradient fields," SPIE's International Symposium on Optical & Opto-Electronic Applied Science and Engineering, San Diego, August 2003.

  8. M. Chachisvilis, J.A. Frangos, Y. Zhang, "G Protein-coupled respond to sense fluid shear stress in endothelial cells", The 20th Symposium of the Protein Society, San Diego, CA, 2006.

  9. M. Chachisvilis, J.A. Frangos, Y. Zhang, "G Protein-coupled respond to mechanical perturbation of plasma membrane", 2006 Annual Fall Meeting of the Biomedical Engineering Society, Chicago, Illinois, October 2006.

PATENTS:

  1. 2002 - US 20040067167,  Methods and apparatus for optophoretic diagnosis of cells and particles. 

  2. 2005 - US 20050207940, Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network.

  3. 2 pending applications for US patents.

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