Marcos Intaglietta, Ph.D., M.D. Chairman, Board of Directors
La Jolla Bioengineering Institute
La Jolla, California 
email

  

 

 

 

EDUCATION

California Institute of Technology 
Pasadena, CA

Ph.D.

1963

Applied Mechanics

California Institute of Technology 
Pasadena, CA

M.S.

1959

Mechanical Engineering

University of California, Berkeley
Berkeley, CA

B.S.

1958

Mechanical Engineering

 

EXPERIENCE 

1976 - Current  Professor of Applied Mechanics and Bioengineering 
University of California San Diego
La Jolla, CA.
1966 - 1976  Assistant and Associate Professor of Applied Mechanics and Bioengineering 
University of California San Diego
La Jolla, CA.
1964 - 1966  Established Investigator
Los Angeles County Heart Association
1963 - 1966  Research Fellow in Engineering Science
California Institute of Technology 
Pasadena, CA

 

HONORS AND MEMBERSHIPS 

2002

Medal of Merit, Order of Health ADr. Humberto Fernández Moran@, Fundación Médica Ceprosalud, Venezuela.

2002

Biomedical Engineering Society International Award

2002

Doctor of Medicine (honoris causa), Ludwig-Maximilians-University Munich; Munich, Germany

1999

Eugene Landis Award, American Microcirculatory Society

1996

Whittaker Distinguished Lecture Award, Biomedical Engineering Society

1994

Malpighi Gold Medal, European Society for Microcirculation

1994

Abbott Award, European Society for Microcirculation

1994

Member, American Institute of Medical and Biological Engineering

1993

Member, European Academy of Science

1993 

Innovative Instrumentation Award, American Microcirculation Society

1993 

Vth International Symposium on Blood Substitutes Award

1989

Intensive Care Medicine Award 1989 , 10th International Symposium on Current Problems in Emergency and Intensive Care Medicine, Münster, Germany

1989

Honorary Member, French Society for Microcirculation

1988

Charter Member, Rho Chapter, International Scholar Society Phi Beta Delta

1988

Honorary Founding Member and Academic Witness, Mexican Society for Microcirculation  

1985 - 1986

President, American Microcirculatory Society

1985

Honorary Member, Italian Society of Microangiology and Microcirculation

1985

Honorary Professor, Chinese Academy of Medical Sciences Beijing, China

1984

Abbott Distin­guished Professor Lecture Series Award, Caracas, Maracaibo, Rio de Janeiro

1983

Founding Director, International Institute for Microcirculation

1982 - 1983

Humboldt Press Senior Scientist Award, Federal Republic of Germany

1974

Visiting Research Scientist Award, Hoffman La‑Roche Foundation, Basel, Switzerland

 

PUBLICATIONS (selected from 191 peer-reviewed publications)

  1. Kerger, H., Saltzman, D.J., Menger, M.D., Messmer, K. and M. Intaglietta. Systemic and subcutaneous microvascular pO2 dissociation during 4-h hemorrhagic shock in conscious hamsters. Am. J. Physiol. 270(Heart. Circ. Physiol. 39):H827-H836, 1996.

  2. Intaglietta, M., Johnson, P.C. and R.M. Winslow. Microvascular and tissue oxygen distribution. Cardiovasc. Res. 32:632-643, 1996.

  3. Kerger, H., Saltzman, D.J., Gonzales, A., Tsai, A.G., Van Ackern, K., Winslow, R.M., and M. Intaglietta. Microvascular oxygen delivery and interstitial oxygenation during sodium pentobarbital anesthesia. Anesthesiol. 86:372-386, 1997.

  4. Kerger, H., Tsai, A.G., Saltzman, D.J., Winslow, R.M. and M. Intaglietta. Fluid resuscitation with O2 vs. non-O2 carriers after 2 h of hemorrhagic shock in conscious hamsters. Am. J. Physiol. 272(Heart. Circ. Physiol. 31):H525-H537, 1997.

  5. Fagrell, B. and M. Intaglietta. Microcirculation: Its significance in clinical and molecular medicine. J. Int. Med. 241:349-362, 1997.

  6. Intaglietta, M.  Whitaker Lecture 1996:  Microcirculation, Biomedical Engineering and artificial blood. Ann. Biomed. Eng. 25:593-603, 1997.

  7. Sakai, H. Tsai, A.G., Kerger, H., Park, S.I., Takeoka, S., Nishide H. and E. Tsuchida and M. Intaglietta.  Subcutaneous microvascular responses to hemodilution with a red cell substitute consisting of polyethyleneglycol-modified vesicles encapsulating hemoglobin. J. Biomed. Mater. Res. 40:66-78, 1998.

  8. Tsai, A.G., Friesenecker, B., Mazzoni, M.C., Kerger, H., Buerk, D.G., Johnson, P.C. and M. Intaglietta. Microvascular and tissue oxygen gradients in the rat mesentery. Proc. Natl. Acad. Sci. USA. 95:6590-6595, 1998

  9. U.S. Patent 5,814,601.  Methods and compositions for optimization of oxygen transport by cell free systems.  R.M. Winslow and M. Intaglietta, 1998.

  10. Buerk, D.G., Tsai, A.G., Intaglietta, M. and P.C. Johnson. In vivo tissue pO2 measurements in hamster skinfold by recessed pO2 microelectrodes and phosphorescence quenching are in agreement.  Microcirculation, 5:219-226, 1998.

  11. Tsai, A.G., Friesenecker, B., McCarthy, M., Sakai, H. and M. Intaglietta. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am. J. Physiol., 275:(Heart. Circ. Physiol. 44):H2170-H2180, 1998.

  12. Sakai, H., Tsai, A.G. Rohlfs, R.J., Hara, H., Takeoka, S., Tsuchida, E., and M. Intaglietta. Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O2 affinity. Am. J. Physiol. 276(Heart Circ. Physiol. 45):H553–H562, 1999.

  13. Kerger, H., Waschke, K.F., Ackern, K.V., Tsai, A.G. and M. Intaglietta.  Systemic and microcirculatory effects of autologous whole blood resuscitation in severe hemorrhagic shock.  Am. J. Physiol. 276(6):H2035-2043, 1999.

  14. Erni, D., Sakai, H., Tsai, A.G., Banic, A., Sigurdsson, G.H., and M. Intaglietta.  Heamodyanmics and oxygen tension in the microcirculation of ischeaemic skin flaps after neural blockade and haemodilution.  Br. J. Plastic Surg. 52(7):565-72, 1999.

  15. Sakai, H., Hara, H., Tsai, A.G., Tsuchida, E., Johnson, P.C. and M. Intaglietta. Changes in resistance vessels during hemorrhagic shock and resuscitation in conscious hamster model. Am. J. Physiol. 276(Heart Circ. Physiol. 45): H563–H571, 1999.

  16. Sakai, H., Hara, H., Yuasa, M., Tsai, A.G.,  Takeoka, S, Tsuchida, E. and M. Intaglietta. Molecular dimensions of Hb-based O2 carriers determine constriction of resistance arteries and hypertension. Am J. Physiol. 279(3): H908-915, 2000.

  17. Sakai, H., Hara, H., Tsai, A.G., Tsuchida, E. and M. Intaglietta. Contriction of resistance arteries determines L-NAME-induced hypertension in a conscious hamster model.  Microvasc. Res.  60(1):21-27, 2000.

  18. Bishop, J.J., Nance, PR, Popel AS, Intaglietta M, Johnson, P.C.  Effect of erythrocyte aggregation on velocity profiles in venules.  Am. J. Physiol. 280(1):H222-236, 2001.

  19. Tsai, A.G. and M. Intaglietta.  High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger.  Biorheology 38(2): pg 229-238, 2001.

  20. Tsai, A.G. and M. Intaglietta.  Hemodilution and increased plasma viscosity for the design of new plasma expanders.  Transfusion Alternative in Transfusion Medicine 3(1):21-23, 2001.

  21. Bishop, J.J., Popel, A.S., Intaglietta, M. and P.C. Johnson. “Effects of erythrocyte aggregation and venous network geometry on red blood cell axial migration”.  Am. J. Physiol. Heart Circ. Physiol. 281:H939-H950, 2001.

  22. Bishop, J.J., Nance, P.R., Popel, A.S., Intaglietta, M. and P.C. Johnson. “Erythrocyte margination and sedimentation in skeletal muscle venules”.  Am. J. Physiol. Heart Circ. Physiol. 281:H951-H958, 2001.

  23. Bishop J.J., Popel A.S., Intaglietta M., and P.C. Johnson.  “Rheological effects of red blood cell aggregation in the venous network: a review of recent studies.”  Biorheology.  38(2-3):263-274, 2001.

  24. Mazzoni M.C., Tsai, A.G., and M. Intaglietta.  “Blood and plasma viscosity and microvascular function in hemodilution. A perspective from La Jolla, California.”  Eur. Surg. Res.  34(1-2):101-105, 2002.

  25. Tsai A.G., and M. Intaglietta.  “The unusual properties of effective blood substitutes.”  Keio  J. Med.  51(1):17-20, 2002.

  26. Haidekker M.A., Tsai A.G., Brady T., Stevens H.Y., Frangos J.A., Theodorakis E., and M. Intaglietta.  “A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors.  Am. J. Physiol. Heart Circ Physiol.  282(5):H1609-H1614, 2002.

  27. Sakai H., Takeoka S., Wettstein R., Tsai A.G., Intaglietta M., and E. Tsuchida.  “Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles.”  Am. J. Physiol. Heart Circ. Physiol.  283(3):H1191-1199, 2002.

  28. Bishop J.J., Popel A.S., Intaglietta M., and P.C. Johnson.  “Effect of aggregation and shear rate on the dispersion of red blood cells flowing in venules.  Am. J. Physiol. Heart Circ. Physiol.  283(5):H1985-1996, 2002.

  29. Kerger H., Groth G., Kalenka A., Vajkoczy P., Tsai A.G., and M. Intaglietta.  pO2 measurements by phosphorescencequenching: characteristics and applications of an automated system.  Microvasc. Res.  65(1):32-38, 2003.

 

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