:: La Jolla Bioengineering Institute

Michael Nicolaou, Ph.D.
Member, Board of Directors
La Jolla Bioengineering Institute
La Jolla, California
email

EDUCATION

University of Kansas Lawrence, KS	Ph.D.	1996	Pharmaceutical Chemistry
University of Kansas Lawrence, KS	M.S.	1992	Pharmaceutical Chemistry
University of Michigan Ann Arbor, MI	B.S.	1990	Chemistry

EXPERIENCE

2002 - Current	Principal Scientist/CEO Nicopharm Pharmaceutical Solutions San Diego, CA.
2002 - 2003	Associate Director of Chemistry and Formulations Epimmune, Inc. San Diego, CA.
1999 - 2001	Founder and President Yasoo Health, Inc. San Diego, CA.
1996 - 1999	Staff Scientist Amylin Pharmaceuticals, Inc. San Diego, CA.

PUBLICATIONS

B. Wang, M. G. Nicolaou S. Liu and R. T. Borchardt,"Structural Analysis of a Fast Lactonization System," Bioorg. Chem., 24, 39-49, 1996.
M. G. Nicolaou, J. Wolfe, R. L. Showen and R. T. Borchardt, "Facilitated Intramolecular Conjugate Addition of Amides of 3-(3',6'-dioxo-2',4'-dimethyl-1',4'-cyclohexadiene)-3,3-Dimethyl propionic Acid. Kinetics of Degradation." J. Org. Chem., 1996, 61, 6633-6638.
M. G. Nicolaou and R. T. Borchardt, "Alkaline Phosphatase-Sensitive Prodrugs for Amines that Utilize a Fast Hydroxy-Amide Lactonization. The Effect of the amine structure," J. Org. Chem., 1996, 61, 8636-8641.
S. Liu, B. Wang, M. G. Nicolaou, and R. T. Borchardt, " "Trimethyl Lock" facilitated spirocyclizations: a structural analysis.” J. Chem. Crystallogr. 26, 209-214, 1996.
D. Shan, M. G. Nicolaou, R. T. Borchardt and B. Wang, “Prodrug Strategies based on Intramolecular Cyclization Reactions,” J. Pharm. Sci , 1997, 86, 765-767.
Nicolaou M. G., Chang P and Newman MJ, “Use of Poly(N-vinyl pyrrolidone) (PVP) with noncondensed plasmid DNA formulations for gene therapy and vaccines”. Gene Therapy CRC Press, (in press).

PRESENTATIONS AND MEETINGS

M. G. Nicolaou and R. T. Borchardt "Prodrugs for Amines that Utilize a Fast Hydroxy-Amide Lactonization" 26th Graduate Student Meeting in Pharmaceutics, June 1994, Omaha, Nebraska, podium presentation.
B. Wang, M. G. Nicolaou, S. Liu and R. T. Borchardt, "Structural Analysis of a Fast Lactonization System," 208th American Chemical Society National Meeting, August 1994, Washington DC, poster presentation.
M. G. Nicolaou and R. T. Borchardt," Phosphate Prodrugs of Amines Which Utilize a Fast Hydroxy-Amide Lactonization." AAPS meeting, November 1994, San Diego, CA, poster presentation.
M. G. Nicolaou, Chong-Sheng Yuan and R. T. Borchardt " Phosphate Prodrugs for Amines Which Utilize A Fast Hydroxy-Amide Lactonization. Structural Specificity for Alkaline Phosphatase." 27th Graduate Student Meeting in Pharmaceutics, June 1995, Ann Arbor Michigan, podium presentation.
M. G. Nicolaou, Chong-Sheng Yuan and R. T. Borchardt " Phosphate Prodrugs for Amines Which Utilize A Fast Hydroxy-Amide Lactonization. Structural Specificity for Alkaline Phosphatase." AAPS meeting, November 1995, Miami Beach, FL, poster presentation.