Tsai, A.G., Lindbom, L., Arfors, K.-E. and M. Intaglietta. “The effect of
vasomotion on exchange in the microvascular network.” In: Microvascular
Networks: Experimental and Theoretical Studies. (A. Popel and P. Johnson
Eds.). pp 99-111, Karger, Basel 1986.
Fagrell, B., Aver, S., Intaglietta, M. and A.G. Tsai. “Changes of activated
partial thromboplastin time during constant intravenous and fixed intermittent
subcutaneous administration.” J. Internal Med. 225:257-260, 1989.
Tsai, A.G. and M. Intaglietta.”"Local tissue oxygenation during constant red
blood cell flux: A discrete source analysis of velocity and hematocrit
changes.” Microvas. Res. 37:308-322, 1989.
Tsai, A.G., Arfors, K.-E. and M. Intaglietta: “Spatial distribution of red blood
cells in individual skeletal muscle capillaries during extreme hemodilution.”
Int. J. Microcirc.: Clin. Exp. 10:317-334, 1991.
Tsai, A.G. and M. Intaglietta: “Changes in tissue oxygenation when subjected
to statistically distributed sources.” Microvasc. Res. 44(2):200-13, 1992.
Tsai, A.G., Nolte, D., Messmer, K. and M. Intaglietta: “Effect of OxygentTM
(Perflubron emulsion) on leukocyte-endothelial interaction in postcapillary
venules.” Biomat., Art. Cells & Immob. Biotech. 20(2-4):959-61, 1992.
Tsai, A.G. and M. Intaglietta: “Evidence of flowmotion induced changes in
local tissue oxygenation.” Int. J. Microcirc.:Clin. Exp. 12(1):75-88, 1993.
Friesenecker, B., Tsai, A.G., Allegra, C. and M. Intaglietta. "Oral
administration of purified micronized flavonoid fraction suppresses leukocyte
adhesion in ischemia-reperfusion injury: In vivo observations in the hamster
skinfold.” Int. J. Microcirc. 14:50-55, 1994.
Friesenecker, B., Tsai, A.G. and M. Intaglietta. “Capillary perfusion during
ischemia reperfusion in subcutaneous connective tissue and skin muscle.”
Am. J. Physiol. 267(Heart. Circ. Physiol. 36):H2204-2212, 1994.
Tsai, A.G., Friesenecker, B., Winslow, R.M. and M. Intaglietta. “Functional
capillary density changes during blood substitution with ""Hb and dextran
70: Influence on oxygen delivery.” Art. Cells, Blood Substitutes, and Immob.
Biotech. 22(3):841-847, 1994.
Friesenecker, B., Tsai, A.G. and M. Intaglietta. “Cellular basis of
inflammation, edema and the activity of Daflon 500 mg.” Int. J. Microcirc.:
Clin. Exp. 15(suppl. 1):17-21, 1995.
Tsai, A.G., Friesenecker, B. and M. Intaglietta. “Capillary flow impairment and
functional capillary density.” Int. J. Microcirc.: Clin. Exp. 15(suppl. 5):238-243,
1995.
Kerger, H., Tsai, A.G., Saltzman, D., Winslow, R.M. and M. Intaglietta. “Fluid
resuscitation with O2 versus non- O2 carriers after 2-hr hemorrhagic shock in
conscious hamsters.” Am. J. Physiol. 270 (Heart. Circ. Physiol. 39):H827-H36, 1996.
Kerger, H., Saltzman, D.J., Gonzales, A., Tsai, A.G., Van Ackern, K.,
Winslow, R.M. and M. Intaglietta. “Microvascular oxygen delivery and
interstitial oxygenation during sodium pentobarbital anesthesia.” Anesthesiol.
86:372-386, 1997.
Sakai, H. Tsai, A.G., Kerger, H., Park, S.I., Takeoka, S., Nishide H.,
Tsuchida, E. and M. Intaglietta. “Subcutaneous microvascular responses to
hemodilution with a red cell substitute consisting of polyethyleneglycolmodified
vesicles encapsulating hemoglobin.” J. Biomed. Mater. Res. 40:66-78, 1998.
Buerk, D.G., Tsai, A.G., Intaglietta, M. and P.C. Johnson. “Comparing tissue
pO2 measurements by recessed microelectrode and phosphorescence quenching.” Adv. Exp. Med. 367-374, 1998.
Tsai, A.G., Kerger, H. and M. Intaglietta. “Microcirculatory consequences of
blood substitution with hemoglobin solutions.” In: Red Blood Cell Substitutes.
Basic Principles and Clinical Applications. (A.S. Rudolph, R. Rabinovich, G.Z.
Feurestein, eds.) Marcel Dekker, Inc. New York, pp. 69-78, 1998.
Tsai, A.G., Friesenecker, B., Mazzoni, M.C., Kerger, H., Buerk, D.G.,
Johnson, P.C. and M. Intaglietta. “Microvascular and tissue oxygen gradients
in the rat mesentery.” Proc. Natl. Acad. Sci. USA. 95:6590-6595, 1998.
Tsai, A.G., Kerger, H. and M. Intaglietta. “Oxygen distribution and
consumption by the microcirculation and the determinants of tissue survival.”
In: Tissue Oxygenation in Acute Medicine (W.J. Sibald, K. Messmer, M.P.
Fink, eds.) Springer, Berlin pp. 55-62, 1998.
Buerk, D.G., Tsai, A.G., Intaglietta, M. and P.C. Johnson. “In vivo tissue pO2
measurements in hamster skinfold by recessed pO2 microelectrodes and
phosphorescence quenching are in agreement.” Microcirc. 5:219-225, 1998.
Tsai, A.G., Friesenecker, B., McCarthy, M., Sakai, H. and M. Intaglietta.
“Plasma viscosity regulates capillary perfusion during extreme hemodilution
in hamster skinfold model.” Am. J. Physiol. 275 (Heart. Circ. Physiol. 44):
H2170-H2180, 1998.
Sakai, H., Tsai, A.G., Rohlfs, R.J., Hara, H., Takeoka, S., Tsuchida, E. and
M. Intaglietta. “Microvascular responses to hemodilution with Hb vesicles as
red blood cell substitutes: influence of O2 affinity.” Am. J. Physiol. 276: (Heart
Circ. Physiol. 45): H553-H562, 1999.
Sakai, H., Hara, H., Tsai, A.G., Tsuchida, E., Johnson, P.C. and M.
Intaglietta. “Changes in resistance vessels during hemorrhagic shock and
resuscitation in conscious hamster model.” Am. J. Physiol. 276: (Heart Circ.
Physiol. 44): H563-H571, 1999.
Kerger, H., Waschke, K.F., v. Ackern, K., Tsai, A.G. and M. Intaglietta.
“Systemic and microcirculatory effects of autologous whole blood
resuscitation in severe hemorrhagic shock.” Am. J. Physiol. 276: (Heart Circ.
Physiol. 45):H2035-H2043, 1999.
Erni, D., Sakai, H., Tsai, A.G., Sigurdssom, G.H. and M. Intaglietta.
“Haemodynamics and oxygen tension in the microcirculation of ischemic skin
flaps after neural blockade and haemodilution.” Brit. J. of Plastic Sur.
52:565-572, 1999.
Tsai, A.G., Sakai, H., Tsuchida, E. and M. Intaglietta. “Mechanical,
microvascular and cellular basis for the design of artificial blood.” Artificial
Blood: 8(2):30-39, 2000.
Sakai, H., Hara, H., Yuasa, M., Tsai, A.G., Takeoka, S., Tsuchida, E. and M.
Intaglietta. “Molecular dimensions of Hb-based pO2 carriers determine
constriction of resistance arteries and hypertension.” Am. J. Physiol. 279:
H908-H915, 2000.
Sakai, H., Hara, H., Tsai, A.G., Tsuchida, E. and M. Intaglietta. “Constriction
of resistance arteries determines L-NAME-induced hypertension in conscious
hamster model”. Microvasc. Res. 60:21-27, 2000.
Tsai, A.G. “Influence of cell-free hemoglobin on local tissue perfusion and
oxygenation after acute anemia following isovolemic hemodilution.”
Transfusion 41(10):1290-1298, 2001.
Tsai, A.G. and M. Intaglietta. “High viscosity plasma expanders: Volume
restitution fluids for lowering the transfusion trigger.”
Biorheol. 38:229-237, 2001.
Tsai, A.G. and M. Intaglietta. “Hemodilution and increased plasma viscosity
for the design of new plasma expanders.” Transfusion Alternatives in
Transfusion Medicine 3:17-23, 2001.
Tsai, A.G. and M. Intaglietta. “The unusual properties of effective blood
subsitutes”. Keio J. Med. 51(1):17-20, 2002.
Haidekker, M.A., Tsai, A.G., Brady, T., Stevens, H.Y., Frangos, J.A.,
Theodorakis, E. and M. Intaglietta. “A novel approach to blood plasma
viscosity measurements using fluorescent molecular rotors”. Am. J. Physiol.
Heart Circ. Physiol. 282:H1600-1614, 2002.
Sakai, H., Takeoka, S., Wettstein, R., Tsai, A.G., Intaglietta, M., and E.
Tsuchida. “Systemic and microvascular responses to hemorrhagic shock and
resuscitation with Hb vesicles.” Am. J. Physiol. Heart Circ. Physiol.
283:H1191-1199, 2002.
Kerger, H., Groth, G., Kalenka, A., Vajkoczy, P., Tsai, A.G. and M. Intaglietta.
“pO2 measurements by phosphorescence quenching: characteristics and
applications of an automated system”. Microvasc. Res. 65:32-38, 2003.
Manjula, B.N., Tsai, A.G., Upadhya, R., Perumalsamy, K., Smith, P.K.,
Malavalli, A., Vandegriff, K., Winslow, R.M., Intaglietta, M., Prabhakaran, M.,
Friedman, J.M. and A.S Acharya. “Site-specific PEGylation of Hemoglobin
at Cys-93($): Correlation between the colligative properties of the PEGylated
Protein and the length of the conjugated PEG chain”. Bioconjugate Chem,
2003.
Makale, M.T., Lin, J.T., Calou, RE., Tsai, A.G., Chen, P.C. and D.A. Gough.
“Tissue window chamber system for validation of implanted oxygen
sensors” Am. J. Physiol. Heart Circ. 284:H2288-H2294, 2003.
Wettstein, R., Tsai, A.G., Erni, D., Winslow, R.M. and M. Intaglietta.
“Resuscitation with polyethylene glycol-modified human hemoglobin improves
microcirculatory blood flow and tissue oxygenation after hemorrhagic shock
in awake hamsters”. Crit Care Med. 31:1824-1830, 2003.
Tsai, A.G., Vandegriff, K.D., Intaglietta, M. and R.M. Winslow. “Targeted O2
delivery by low-P50 hemoglobin: a new basis for O2 therapeutics”. Am. J.
Physiol. Heart Circ. 285:H1411-H1419, 2003.
Tsai,
A.G., Carbales, P., Winslow, R.M. and M. Intaglietta.
“Microvascular oxygen distribution in awake hamster window chamber model during
hypoxia”. Am. J. Physiol. Heart Circ. 285:H1537-H1545, 2003.
Saltzman, D.J., Toth, A., Tsai, A.G., Intaglietta, M. and P.C. Johnson.
“Oxygen tension distribution in postcapillary venules in resting skeletal
muscle”. Am. J. Physiol. Heart Circ. 285:H1980-H1985, 2003.
Tsai, A.G., Johnson, P.C. and M. Intaglietta. “Oxygen gradients in the
microcirculation”. Physiol. Rev. 83:933-963, 2003. (from Work in Progress)
Cabrales, P., Acero, C., Intaglietta, M. and A.G. Tsai. “Measurement of the
cardiac output in small animals by thermodilution”. Microvasc. Res. 66:77-82, 2003.
Saldivar, E., Cabrales, P., Tsai, A.G. and M. Intaglietta. “Microcirculatory
changes during chronic adaptation to hypoxia”. Am. J. Physiol. Heart Circ.
285:H2064-H2071, 2003.
Briceno, J.C., Cabrales, P., Tsai, A.G., and M. Intaglietta. “Radial
displacement of red blood cells during hemodilution and the effect on
arteriolar oxygen profile.” Am. J. Physiol. Heart Circ. 286:H1223-H1228,
2004.
Hangai-Hoger, N., Cabrales, P., Briceno, J.C., Tsai, A.G. and M. Intaglietta.
“Microlymphatic and tissue oxygen tension in the rat mesentery”. Am. J.
Physiol. Heart Circ. 286:H878-H883, 2004.
Tsai, A.G., Sakai, H., Wettstein, R., Kerger, H. And M. Intaglietta. “An
effective blood replacement fluid that targets oxygen delivery, increases
plasma viscosity, and has high oxygen affinity”. TATM. 5(6):507-515, 2004.
Wettstein, R., Tsai, A.G., Erni, D., Lukyanov, A.N., Torchilin, V.P. and M.
Intaglietta. “Improving microcirculation is more effective than substitution of
red blood cells to correct metabolic disorder in experimental hemorhhagic
shock”. Shock. 21:235-240, 2004.
Cabrales, P., Tsai, A.G. and M. Intaglietta. “Microvascular pressure and
functional capillary density in extreme hemodilution with low- and highviscosity
dextran and a low-viscosity Hb-based O2 carrier”. Am. J. Physiol.
Heart Circ. 287:H363-H373. 2004.
Cabrales, P., Tsai, A.G., Frangos, J.A., Briceno, J.C. and M. Intaglietta.
“Oxygen delivery and consumption in the microcirculation after extreme
hemodilution with perfluorocarbons”. Am. J. Physiol. Heart Circ. 287(1):320-330, 2004.
Tsai, A.G., Cabrales, P. And M. Intaglietta. “Oxygen-carrying blood
substitutes: a microvascular prespective.” Expert Opin. Biol. Therapy 4(7):1147-1157, 2004.
Cabrales, P., Devi Kanika, N., Manjula, B.N., Tsai, A.G., Acharya, S.A., and
M. Intaglietta. “Microvascular pO2 during extreme hemodilution with
hemoglobin site specifically pegylated at CYS-93($) in hamster window
chamber”. Am. J. Physiol. Heart Circ. 2004 (in press).
Friesenecker, B., Tsai, A.G., Dunser, M.W., Mayr, A.J., Martini, J., Knotzer,
H., Hasibeder, W. and M. Intaglietta. “Oxygen distribution in the
microcirculation following argenine-vasopressin induced arteriolar
vasoconstriction”. Am J Physiol Heart Circ. 2004 (in press).
Manjula, B.N., Tsai, A.G., Intaglietta, M., Tsai, C.H., Ho, C., Malavalli, A.,
Vandegriff, K.D., Winslow, R.M., Smith, P.K., Perumalsamy, K., Ksanika,
N.D., Friedman, J.M. and S.A. Acharya. “PEGylated hemoglobin: Role of
surface configuration of PEG for the modulation of hemoglobin vasoactivity.”
J. Biol. Chem. 2004 (in press).
Tsai, A.G., Cabrales, P. and M. Intaglietta. “Microvascular perfusion upon
exchange transfusion with stored RBCs in normovolemic anemic conditions”.
Tranfusion. 2004 (accepted for publication)
