EDUCATION

EXPERIENCE 

HONORS AND MEMBERSHIPS  

PUBLICATIONS  

1. Mitoma, J., Petryniak, B, Hiraoka, N., Yeh, J.-C., Lowe, JB and Fukuda, M. (2003)  Extended core 1 and core 2 branched O-glycans differentially modulate sialyl Lewis x-type L-selectin ligand activity.  J. Biol. Chem. 278, 9953-9961

2. Fukuda, M., and Yeh, J.-C. (2002) Core 2 b6-N-acetylglucosaminyltransferase-II.  In Taniguchi, M. Honke, K., and Fukuda, M. (ed) Handbook of Glycosyltransferases and Related Genes.143-150

3. Ong, E., Suzuki, M., Belot, F., Yeh, J.-C., Franceschini, I., Angata, K., Hindsgaul, O., Fukuda, M. (2002) Biosynthesis of the HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM). The requirement for core 2 b-1,6-N-acetylglucosaminyltransferase and the muscle specific domain in NCAM.  J. Biol. Chem. 277, 18182-18190

4. Yeh, J.-C., Hiraoka N, Petryniak B, Nakayama J, Ellies LG, Rabuka D, Hindsgaul O, Marth JD, Lowe, J. B., Fukuda M. (2001)  Novel sulfated lymphocyte homing receptors and their control by a core1 extension b1,3-N-acetylglucosaminyltransferase. Cell 105, 957-969

5. Vanderplasschen, A., Markine-Goriaynoff, N., Lomonte, P., Suzuki, M., Hiraoka, N., Yeh, J.-C., Bureau, F., Willems, L., Thriy, E., Fukuda, M. and Pastoret, P.-P. (2000) A multipotential b-1,6-N-acetylglucosaminyltransferase is encoded by Bovine herpesvirus type 4. Proc. Natl. Acad. Sci. USA 97, 5756-5761

6. Schwientek, T., Yeh, J.-C., Levery, S. B., Keck, B., Merkx, G., van Kessel, A. G.,  Fukuda, M. and Clausen, H. (2000) Control of O-glycan branch formation: Molecular cloning and characterization of a novel thymus-associated core 2 b1,6-N-acetylglucosaminyltransferase.  J. Biol. Chem. 275, 11106-11113

7. Fukuda, M., Hiraoka, N. and Yeh, J.-C. (1999) C-type lectins and sialyl Lewis x oligosaccharides: Versatile roles in cell-cell adhesion. (mini-review)  J.  Cell. Biol.  147, 467-470

8. Ong, E., Yeh, J.-C., Ding, Y., Hindsgaul, O., Pederson, L. C., Negishi, M. and Fukuda, M. (1999)  Structure and function of HNK-1 sulfotransferase:  Identification of donor and acceptor binding sites by site-directed mutagenesis.  J. Biol. Chem. 274, 25608-25612

9. Nakayama, J., Yeh, J.-C., Misra, A., Ito, S., Katsuyama, T. and Fukuda, M. (1999) Expression cloning of a human a-1,4-N-acetylglucosaminyltransferase that forms GlcNAca1,4Galb-H, a unique carbohydrate for the gastric gland mucous cell-type mucin. Proc. Natl. Acad. Sci. USA  96, 8991-8996

10. Hiraoka, N., Petryniak, B., Nakayama, J., Tsuboi S., Suzuki, M., Yeh, J.-C., Izawa, D., Tanaka, T., Miyasaka, M., Lowe, J. B. and Fukuda M. (1999) A novel, high endothelial venule-specific sulfotransferase directs expression of 6-sulfo sialyl Lewis x, an L-selectin ligand displayed by CD34.  Immunity 11, 79-89

11. Yeh, J.-C., Ong, E. and Fukuda, M. (1999)  Molecular cloning and expression of a novel b-1,6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.  J. Biol. Chem. 274, 3215-3221

12. Ong, E., Yeh, J.-C., Ding, Y., Hindsgaul, O. and Fukuda, M. (1998)  Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids.  J. Biol. Chem. 273, 5190-5195

13. *Cho, S. K., *Yeh, J.-C. and Cummings, R. D. (1997)  Secrection of a-1,3-galactosyltransferase by cultured cells and presence of enzyme in animal sera.  Glycoconjugate J.  14, 809-819 *The first two authors are equal contributors to this work

14. Yeh, J.-C. and Cummings, R. D. (1997)  Differential recognition of glycoprotein acceptors by terminal glycosyltransferases.  Glycobiology 7, 241-251

15. Li, S., Neethling, F. A., Taniguchi, S., Yeh, J.-C., Kobayashi, T., Ye, Y.,  Koren, E., Cummings, R. D. and Cooper, D. K. C. (1996)  Glycans derived from porcine stomach mucin are effective inhibitors of natural anti-aGal antibodies in vitro and after intravenous infusion in baboon.  Transplantation 62,1324-1331

16. Li, S., Neethling, F. A., Yeh, J.-C., Cooper, D. K. C. and Cummings, R. D. (1996)  Potent inhibition of human and baboon anti-aGal antibodies by a subfraction of oligosaccharides derived from porcine stomach mucin.  Transplant. Proc.  28, 563

17. Yeh, J.-C. and Cummings, R. D. (1996)  Absorbance- and light-based solid-phase assays for CMPNeuAc:Galb1-4GlcNAc-R a-2,3sialyltransferase.  Anal. Biochem.  236, 126-133

18. Cho, S. K., Yeh, J.-C., Cho, M. and Cummings, R. D. (1996)  Transcriptional regulation of a1,3-galactosyltransferase in embryonal carcinoma cells by retinoic acid: Masking of Lewis x antigens by agalactosylation.  J. Biol. Chem. 271, 3238-3246

19. *Li, S., *Yeh, J.-C., Cooper, D. K. C. and Cummings, R. D. (1995)  Inhibition of human anti-aGal IgG by oligosaccharides derived from porcine stomach mucin.  Xenotransplantation 2, 279-288.       *The first two authors are equal contributors to this work.

20. Wang, C.-S., Dashti, A., Jackson, K. W., Yeh, J.-C., Cummings, R. D. and Tang, J. (1995)  Isolation and characterization of human milk bile salt activated lipase C-tail fragment. Biochemistry  34, 10639-10644

21. Yeh, J.-C., Seals, J. R., Murphy, C. I., van Halbeek, H. and Cummings, R. D. (1993)  Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.  Biochemistry 32, 11087-11099

PATENTS:

1. Genset Corp, San Diego, CA 92121.  Homotrimeric Extended OBG3 Globular Head And Uses Thereof USPTO application serial no. 60/385,238 (filed on 6/14/2002)

2. The Burnham Institute, La Jolla, CA
   b-1-6-N-Acetylglucosaminyltransferase that forms core2, core4 and I branches.  United States Patent # 6,136,580, Oct, 24, 2000. A Novel b1,3-N-Acetylglucosaminyltransferase That Forms the MECA-79 Antigen. 

3. Corvas International, San Diego, CA 92121.  10 patents covering the cloning and sequences of novel serine proteases, and their inhibitors

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