John A. Frangos, PhD
President & CEO/Scientific Director
La Jolla Bioengineering Institute
La Jolla, California
Education
- Rice University, Ph.D. 1986 Chemical Engineering
- Stanford University, M.S. 1982 Chemical Engineering
- Johns Hopkins University, B.E.S. 1981 Chemical Engineering
Experience
2002 – Present Founder, Scientific Director, President & CEO, La Jolla Bioengineering Institute.
1996 – 2002 Professor, Department of Bioengineering, University of California San Diego.
1994 – 1996 Associate Professor, Department of Bioengineering, University of California San Diego.
1992 – 1994 Associate Professor, Department of Chemical Engineering, Penn State University.
1986 – 1992 Assistant Professor, Department of Chemical Engineering, Penn State University.
Honors and Memberships
2009 – 2014 NIH MERIT Award
2002 – 2004 Member, Surgery and Bioengineering Study Section, NIH
1999 Fellow, American Institute for Medical and Biological Engineering
1997 – 1998 Editorial Board, American Journal of Physiology: Heart and Circulatory Physiology
1998 – Present Editorial Board, General Pharmacology
1998 – 2001 American Heart Association Study Committee on Vascular Wall Biology I
1998 – Present External Advisory Board, Program on Mechanotransduction in Bone, Indiana Univ
1997 – 2000 External Advisory Board, NSCORT on Space Cell Biology, Rice University
1997 – 2000 Board of Directors, Biomedical Engineering Society
1997 Program Chair, Annual meeting of Biomedical Engineering Society, San Diego
1997 Board of Scientific Counselors, Nat. Inst. on Deafness & Other Communication Disorders
1993 Y.C. Fung Young Investigator Award, American Society of Mechanical Engineers
1993 – 1996 Councilor, North American Society of Biorheology
1990 – 1995 NSF Presidential Young Investigator Award
1991 Outstanding Research Award, College of Engineering, Penn State University
Selected Publications
Kwon RY, Meays DR, Tang WF, Frangos JA.
Microfluidic enhancement of intramedullary pressure increases intersitital fluid flow and inhibits bone loss in hindlimb suspended mice.
J Bone Miner Res. 2010 Feb 23.
Laura A Otte, Kelly S Bell, Laurent Loufrani, Jiunn-Chern Yeh, Benoit Melchior, Diep N Dao, Hazel Y Stevens, Charles R White & John A Frangos
Rapid changes in shear stress induce dissociation of a G alpha(q/11)-platelet endothelial cell adhesion molecule-1 complex.
The Journal of physiology. 2009 May; 587(Pt 10):2365-73
Hazel Y Stevens, Benoit Melchior, Kelly S Bell, Sujin Yun, Jiunn-Chern Yeh & John A Frangos
PECAM-1 is a critical mediator of atherosclerosis. Disease Models Mechanisms.
Disease models & mechanisms. 2008 Sep-Oct ; 1(2-3):175-81; discussion 179
Jiunn-chern Yeh, Laura A Otte & John A Frangos
Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.
Biochemistry. 2008 Aug; 47(34):9029-39
Dennis H Kim & John A Frangos
Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols.
Biophysical journal. 2008 Jul; 95(2):620-8
Irene Gramaglia, Peter Sobolewski, Diana Meays, Ramiro Contreras, John P Nolan, John A Frangos, Marcos Intaglietta & Henri C van der Heyde
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.
Nature medicine. 2006 Dec; 12(12):1417-22