John A. Frangos
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Publications
Kwon RY, Meays DR, Tang WF, Frangos JA.
Microfluidic enhancement of intramedullary pressure increases intersitital fluid flow and inhibits bone loss in hindlimb suspended mice.
J Bone Miner Res. 2010 Feb 23.
Pedro Cabrales, Graziela M Zanini, Diana Meays, John A Frangos & Leonardo J M Carvalho
Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction, and Survival upon Rescue Treatment Is Markedly Increased by Nimodipine.
The American journal of pathology. 2010 Jan; 176(3):1306-15
Y Zhang, JA Frangos and Chachisvilis, M
Mechanotransduction by membrane mediated activation of G protein coupled receptors and G proteins
Cellular Mechanotransduction, eds M. Mofrad and R. Kamm, Cambridge University Press, 2009
Yan-Liang Zhang, John A Frangos & Mirianas Chachisvilis
Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.
American journal of physiology. Cell physiology. 2009 Jun; 296(6):C1391-9
Hema Rangaswami, Nisha Marathe, Shunhui Zhuang, Yongchang Chen, Jiunn-Chern Yeh, John A Frangos, Gerry R Boss & Renate B Pilz
Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction.
The Journal of biological chemistry. 2009 May; 284(22):14796-808
Laura A Otte, Kelly S Bell, Laurent Loufrani, Jiunn-Chern Yeh, Benoit Melchior, Diep N Dao, Hazel Y Stevens, Charles R White & John A Frangos
Rapid changes in shear stress induce dissociation of a G alpha(q/11)-platelet endothelial cell adhesion molecule-1 complex.
The Journal of physiology. 2009 May; 587(Pt 10):2365-73
Hazel Y Stevens, Benoit Melchior, Kelly S Bell, Sujin Yun, Jiunn-Chern Yeh & John A Frangos
PECAM-1 is a critical mediator of atherosclerosis. Disease Models Mechanisms.
Disease models & mechanisms. 2008 Sep-Oct ; 1(2-3):175-81; discussion 179
Hiromi Sakai, Atsushi Sato, Peter Sobolewski, Shinji Takeoka, John A Frangos, Koichi Kobayashi, Marcos Intaglietta & Eishun Tsuchida
NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.
Biochimica et biophysica acta. 2008 Oct; 1784(10):1441-7
Jiunn-chern Yeh, Laura A Otte & John A Frangos
Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.
Biochemistry. 2008 Aug; 47(34):9029-39
J A Frangos, L V McIntire & S G Eskin
Shear stress induced stimulation of mammalian cell metabolism.
Biotechnology and bioengineering. 1988 Oct; 32(8):1053-60
Dennis H Kim & John A Frangos
Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols.
Biophysical journal. 2008 Jul; 95(2):620-8
Charles R White & John A Frangos
The shear stress of it all: the cell membrane and mechanochemical transduction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2007 Aug; 362(1484):1459-67
Antony K Chen, Michael I Latz, Peter Sobolewski & John A Frangos
Evidence for the role of G-proteins in flow stimulation of dinoflagellate bioluminescence.
American journal of physiology. Regulatory, integrative and comparative physiology. 2007 May; 292(5):R2020-7
Ramiro Contreras, Herman Sahlin & John A Frangos
Titanate biomaterials with enhanced antiinflammatory properties.
Journal of biomedical materials research. Part A. 2007 Feb; 80(2):480-5
Irene Gramaglia, Peter Sobolewski, Diana Meays, Ramiro Contreras, John P Nolan, John A Frangos, Marcos Intaglietta & Henri C van der Heyde
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.
Nature medicine. 2006 Dec; 12(12):1417-22
Mirianas Chachisvilis, Yan-Liang Zhang & John A Frangos
G protein-coupled receptors sense fluid shear stress in endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America. 2006 Oct; 103(42):15463-8
Yulian Wang, Benjamin S Maciejewski, Nicole Lee, Ophira Silbert, Nathan L McKnight, John A Frangos & Juan Sanchez-Esteban
Strain-induced fetal type II epithelial cell differentiation is mediated via cAMP-PKA-dependent signaling pathway.
American journal of physiology. Lung cellular and molecular physiology. 2006 Oct; 291(4):L820-7
H Y Stevens, D R Meays & J A Frangos
Pressure gradients and transport in the murine femur upon hindlimb suspension.
Bone. 2006 Sep; 39(3):565-72
Yan-Liang Zhang, John A Frangos & Mirianas Chachisvilis
Laurdan fluorescence senses mechanical strain in the lipid bilayer membrane.
Biochemical and biophysical research communications. 2006 Sep; 347(3):838-41
M Intaglietta & J A Frangos
Introduction: mechanotransduction and translational medicine workshop.
Journal of internal medicine. 2006 Apr; 259(4):336-8
Herman Sahlin, Ramiro Contreras, Daniel F Gaskill, Lars M Bjursten & John A Frangos
Anti-inflammatory properties of micropatterned titanium coatings.
Journal of biomedical materials research. Part A. 2006 Apr; 77(1):43-9
H Y Stevens, D R Meays, J Yeh, L M Bjursten & J A Frangos
COX-2 is necessary for venous ligation-mediated bone adaptation in mice.
Bone. 2006 Jan; 38(1):93-104
Irene Gramaglia, Herman Sahlin, John P Nolan, John A Frangos, Marcos Intaglietta & Henri C van der Heyde
Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria.
Journal of immunology (Baltimore, Md. : 1950). 2005 Dec; 175(11):7699-707
Charles R White, Hazel Y Stevens, Mark Haidekker & John A Frangos
Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells.
American journal of physiology. Heart and circulatory physiology. 2005 Dec; 289(6):H2350-5
Judith Martini, Benoit Carpentier, Adolfo Chavez Negrete, John A Frangos & Marcos Intaglietta
Paradoxical hypotension following increased hematocrit and blood viscosity.
American journal of physiology. Heart and circulatory physiology. 2005 Nov; 289(5):H2136-43
Charles Ray White, Mohammad Wael Hamade, Koushan Siami, Melody M Chang, Anandit Mangalwadi, John A Frangos & William J Pearce
Maturation enhances fluid shear-induced activation of eNOS in perfused ovine carotid arteries.
American journal of physiology. Heart and circulatory physiology. 2005 Nov; 289(5):H2220-7
Pedro Cabrales, Amy G Tsai, John A Frangos & Marcos Intaglietta
Role of endothelial nitric oxide in microvascular oxygen delivery and consumption.
Free radical biology & medicine. 2005 Nov; 39(9):1229-37
Peter Sobolewski, Irene Gramaglia, John A Frangos, Marcos Intaglietta & Henri van der Heyde
Plasmodium berghei resists killing by reactive oxygen species.
Infection and immunity. 2005 Oct; 73(10):6704-10
Zsolt Bagi, John A Frangos, Jiunn-Chern Yeh, Charles R White, Gabor Kaley & Akos Koller
PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress.
Arteriosclerosis, thrombosis, and vascular biology. 2005 Aug; 25(8):1590-5
Peter Sobolewski, Irene Gramaglia, John A Frangos, Marcos Intaglietta & Henri C van der Heyde
Hemoglobin serves to protect Plasmodium parasites from nitric oxide and reactive oxygen species.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2005 Jul; 53(5):2
Amy G Tsai, Cesar Acero, Patricia R Nance, Pedro Cabrales, John A Frangos, Donald G Buerk & Marcos Intaglietta
Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion.
American journal of physiology. Heart and circulatory physiology. 2005 Apr; 288(4):H1730-9
N Dusserre, N L'Heureux, K S Bell, H Y Stevens, J Yeh, L A Otte, L Loufrani & J A Frangos
PECAM-1 interacts with nitric oxide synthase in human endothelial cells: implication for flow-induced nitric oxide synthase activation.
Arteriosclerosis, thrombosis, and vascular biology. 2004 Oct; 24(10):1796-802
Pedro Cabrales, Amy G Tsai, John A Frangos, Juan C Briceño & Marcos Intaglietta
Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons.
American journal of physiology. Heart and circulatory physiology. 2004 Jul; 287(1):H320-30
Mark A Haidekker, Hazel Y Stevens & John A Frangos
Cell membrane fluidity changes and membrane undulations observed using a laser scattering technique.
Annals of biomedical engineering. 2004 Apr; 32(4):531-6
A P Bergula, M A Haidekker, W Huang, H Y Stevens & J A Frangos
Venous ligation-mediated bone adaptation is NOS 3 dependent.
Bone. 2004 Mar; 34(3):562-9
Charles R White, Mark A Haidekker, Hazel Y Stevens & John A Frangos
Extracellular signal-regulated kinase activation and endothelin-1 production in human endothelial cells exposed to vibration.
The Journal of physiology. 2004 Mar; 555(Pt 2):565-72
Mark A Haidekker, Hazel Y Stevens & John A Frangos
Computerized methods for X-ray-based small bone densitometry.
Computer methods and programs in biomedicine. 2004 Jan; 73(1):35-42
Craig B Clark, Nathan L McKnight & John A Frangos
Stretch activation of GTP-binding proteins in C2C12 myoblasts.
Experimental cell research. 2004 Jan; 292(2):265-73
A Battaglia, K Pak, D Brors, D Bodmer, J A Frangos & A F Ryan
Involvement of ras activation in toxic hair cell damage of the mammalian cochlea.
Neuroscience. 2003 ; 122(4):1025-35
Richard Suzuki, Julie Muyco, Joanna McKittrick & John A Frangos
Reactive oxygen species inhibited by titanium oxide coatings.
Journal of biomedical materials research. Part A. 2003 Aug; 66(2):396-402
Sivaramaprasad Gudi, Ivana Huvar, Charles R White, Nathan L McKnight, Nathalie Dusserre, Gerry R Boss & John A Frangos
Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology. 2003 Jun; 23(6):994-1000
Antony K Chen, Michael I Latz & John A Frangos
The use of dinoflagellate bioluminescence to characterize cell stimulation in bioreactors.
Biotechnology and bioengineering. 2003 Jul; 83(1):93-103
Hazel Y Stevens & John A Frangos
Bone cell responses to fluid flow.
Methods in molecular medicine. 2003 ; 80():381-98
Nathan L McKnight & John A Frangos
Strain rate mechanotransduction in aligned human vascular smooth muscle cells.
Annals of biomedical engineering. 2003 Mar; 31(3):239-49
Craig B Clark, Nathan L McKnight & John A Frangos
Strain and strain rate activation of G proteins in human endothelial cells.
Biochemical and biophysical research communications. 2002 Nov; 299(2):258-62
Mark A Haidekker, Thomas Brady, Ke Wen, Cliff Okada, Hazel Y Stevens, Jeniffer M Snell, John A Frangos & Emmanuel A Theodorakis
Phospholipid-bound molecular rotors: synthesis and characterization.
Bioorganic & medicinal chemistry. 2002 Nov; 10(11):3627-36
Guang-Liang Jiang, Charles R White, Hazel Y Stevens & John A Frangos
Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein.
American journal of physiology. Endocrinology and metabolism. 2002 Aug; 283(2):E383-9
S K Mallipattu, M A Haidekker, P Von Dassow, M I Latz & J A Frangos
Evidence for shear-induced increase in membrane fluidity in the dinoflagellate Lingulodinium polyedrum.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 2002 Jun; 188(5):409-16
Mark A Haidekker, Amy G Tsai, Thomas Brady, Hazel Y Stevens, John A Frangos, Emmanuel Theodorakis & Marcos Intaglietta
A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors.
American journal of physiology. Heart and circulatory physiology. 2002 May; 282(5):H1609-14
& A Frangos
The mechanism of mechanosensing by bone.
Journal of biomechanics. 2002 Mar; 35(3):387; author reply 389
M A Haidekker, C R White & J A Frangos
Analysis of temporal shear stress gradients during the onset phase of flow over a backward-facing step.
Journal of biomechanical engineering. 2001 Oct; 123(5):455-63
X Bao, C Lu & J A Frangos
Mechanism of temporal gradients in shear-induced ERK1/2 activation and proliferation in endothelial cells.
American journal of physiology. Heart and circulatory physiology. 2001 Jul; 281(1):H22-9
C R White, M Haidekker, X Bao & J A Frangos
Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation.
Circulation. 2001 May; 103(20):2508-13
M A Haidekker, T Ling, M Anglo, H Y Stevens, J A Frangos & E A Theodorakis
New fluorescent probes for the measurement of cell membrane viscosity.
Chemistry & biology. 2001 Feb; 8(2):123-31
X Bao, C B Clark & J A Frangos
Temporal gradient in shear-induced signaling pathway: involvement of MAP kinase, c-fos, and connexin43.
American journal of physiology. Heart and circulatory physiology. 2000 May; 278(5):H1598-605
T N McAllister, T Du & J A Frangos
Fluid shear stress stimulates prostaglandin and nitric oxide release in bone marrow-derived preosteoclast-like cells.
Biochemical and biophysical research communications. 2000 Apr; 270(2):643-8
M A Haidekker, N L'Heureux & J A Frangos
Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence.
American journal of physiology. Heart and circulatory physiology. 2000 Apr; 278(4):H1401-6
R Suzuki & J A Frangos
Inhibition of inflammatory species by titanium surfaces.
Clinical orthopaedics and related research. 2000 Mar; (372):280-9
Y S Chang, J A Yaccino, S Lakshminarayanan, J A Frangos & J M Tarbell
Shear-induced increase in hydraulic conductivity in endothelial cells is mediated by a nitric oxide-dependent mechanism.
Arteriosclerosis, thrombosis, and vascular biology. 2000 Jan; 20(1):35-42
X Bao, C Lu & J A Frangos
Temporal gradient in shear but not steady shear stress induces PDGF-A and MCP-1 expression in endothelial cells: role of NO, NF kappa B, and egr-1.
Arteriosclerosis, thrombosis, and vascular biology. 1999 Apr; 19(4):996-1003
A P Bergula, W Huang & J A Frangos
Femoral vein ligation increases bone mass in the hindlimb suspended rat.
Bone. 1999 Mar; 24(3):171-7
H Ishizaka, S R Gudi, J A Frangos & L Kuo
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
Circulation. 1999 Feb; 99(4):558-63
M V Hillsley & J A Frangos
Bone tissue engineering: the role of interstitial fluid flow.
Biotechnology and bioengineering. 1994 Mar; 43(7):573-81
S R Gudi, A A Lee, C B Clark & J A Frangos
Equibiaxial strain and strain rate stimulate early activation of G proteins in cardiac fibroblasts.
The American journal of physiology. 1998 May; 274(5 Pt 1):C1424-8
S Gudi, J P Nolan & J A Frangos
Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition.
Proceedings of the National Academy of Sciences of the United States of America. 1998 Mar; 95(5):2515-9
V Shah, F G Haddad, G Garcia-Cardena, J A Frangos, A Mennone, R J Groszmann & W C Sessa
Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids.
The Journal of clinical investigation. 1997 Dec; 100(11):2923-30
H L Knudsen & J A Frangos
Role of cytoskeleton in shear stress-induced endothelial nitric oxide production.
The American journal of physiology. 1997 Jul; 273(1 Pt 2):H347-55
K J Gooch, C A Dangler & J A Frangos
Exogenous, basal, and flow-induced nitric oxide production and endothelial cell proliferation.
Journal of cellular physiology. 1997 Jun; 171(3):252-8
M V Hillsley & J A Frangos
Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow.
Calcified tissue international. 1997 Jan; 60(1):48-53
K M Reich, T N McAllister, S Gudi & J A Frangos
Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts.
Endocrinology. 1997 Mar; 138(3):1014-8
K J Gooch & J A Frangos
Flow- and bradykinin-induced nitric oxide production by endothelial cells is independent of membrane potential.
The American journal of physiology. 1996 Feb; 270(2 Pt 1):C546-51
D L Johnson, T N McAllister & J A Frangos
Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts.
The American journal of physiology. 1996 Jul; 271(1 Pt 1):E205-8
S R Gudi, C B Clark & J A Frangos
Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanochemical signal transduction.
Circulation research. 1996 Oct; 79(4):834-9
S N Alshihabi, Y S Chang, J A Frangos & J M Tarbell
Shear stress-induced release of PGE2 and PGI2 by vascular smooth muscle cells.
Biochemical and biophysical research communications. 1996 Jul; 224(3):808-14
J A Frangos, T Y Huang & C B Clark
Steady shear and step changes in shear stimulate endothelium via independent mechanisms--superposition of transient and sustained nitric oxide production.
Biochemical and biophysical research communications. 1996 Jul; 224(3):660-5
J Klein-Nulend, A van der Plas, C M Semeins, N E Ajubi, J A Frangos, P J Nijweide & E H Burger
Sensitivity of osteocytes to biomechanical stress in vitro.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1995 Mar; 9(5):441-5
J R Botella, R N Arteca & J A Frangos
A mechanical strain-induced 1-aminocyclopropane-1-carboxylic acid synthase gene.
Proceedings of the National Academy of Sciences of the United States of America. 1995 Feb; 92(5):1595-8
H W Sill, Y S Chang, J R Artman, J A Frangos, T M Hollis & J M Tarbell
Shear stress increases hydraulic conductivity of cultured endothelial monolayers.
The American journal of physiology. 1995 Feb; 268(2 Pt 2):H535-43
M J Kuchan, H Jo & J A Frangos
Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells.
The American journal of physiology. 1994 Sep; 267(3 Pt 1):C753-8
L A Garrison, J A Frangos, D B Geselowitz, T C Lamson & J M Tarbell
A new mock circulatory loop and its application to the study of chemical additive and aortic pressure effects on hemolysis in the Penn State electric ventricular assist device.
Artificial organs. 1994 May; 18(5):397-407
M J Kuchan & J A Frangos
Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells.
The American journal of physiology. 1994 Mar; 266(3 Pt 1):C628-36
F Berthiaume & J A Frangos
Fluid flow increases membrane permeability to merocyanine 540 in human endothelial cells.
Biochimica et biophysica acta. 1994 Apr; 1191(1):209-18
T C Lamson, G Rosenberg, D B Geselowitz, S Deutsch, D R Stinebring, J A Frangos & J M Tarbell
Relative blood damage in the three phases of a prosthetic heart valve flow cycle.
ASAIO journal (American Society for Artificial Internal Organs : 1992). ; 39(3):M626-33
K J Gooch & J A Frangos
Shear sensitivity in animal cell culture.
Current opinion in biotechnology. 1993 Apr; 4(2):193-6
K M Reich & J A Frangos
Protein kinase C mediates flow-induced prostaglandin E2 production in osteoblasts.
Calcified tissue international. 1993 Jan; 52(1):62-6
M J Kuchan & J A Frangos
Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells.
The American journal of physiology. 1993 Jan; 264(1 Pt 2):H150-6
H J Hsieh, N Q Li & J A Frangos
Pulsatile and steady flow induces c-fos expression in human endothelial cells.
Journal of cellular physiology. 1993 Jan; 154(1):143-51
F Berthiaume & J A Frangos
Flow-induced prostacyclin production is mediated by a pertussis toxin-sensitive G protein.
FEBS letters. 1992 Aug; 308(3):277-9
H J Hsieh, N Q Li & J A Frangos
Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C.
Journal of cellular physiology. 1992 Mar; 150(3):552-8
K M Reich & J A Frangos
Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts.
The American journal of physiology. 1991 Sep; 261(3 Pt 1):C428-32
P Jarvis, J M Tarbell & J A Frangos
An in vitro evaluation of an artificial heart.
ASAIO transactions / American Society for Artificial Internal Organs. ; 37(1):27-32
H J Hsieh, N Q Li & J A Frangos
Shear stress increases endothelial platelet-derived growth factor mRNA levels.
The American journal of physiology. 1991 Feb; 260(2 Pt 2):H642-6
K M Reich, C V Gay & J A Frangos
Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production.
Journal of cellular physiology. 1990 Apr; 143(1):100-4
A Gupte & J A Frangos
Effects of flow on the synthesis and release of fibronectin by endothelial cells.
In vitro cellular & developmental biology : journal of the Tissue Culture Association. 1990 Jan; 26(1):57-60
J A Frangos, J L Moake, L Nolasco, M D Phillips & L V McIntire
Cryosupernatant regulates accumulation of unusually large vWF multimers from endothelial cells.
The American journal of physiology. 1989 Jun; 256(6 Pt 2):H1635-44
A Bhagyalakshmi & J A Frangos
Mechanism of shear-induced prostacyclin production in endothelial cells.
Biochemical and biophysical research communications. 1989 Jan; 158(1):31-7
L V McIntire, J A Frangos, B G Rhee, S G Eskin & E R Hall
The effect of fluid mechanical stress on cellular arachidonic acid metabolism.
Annals of the New York Academy of Sciences. 1987 ; 516():513-24
J A Frangos, S G Eskin, L V McIntire & C L Ives
Flow effects on prostacyclin production by cultured human endothelial cells.
Science (New York, N.Y.). 1985 Mar; 227(4693):1477-9
Books
Frangos, J.A.
Physical forces and the mammalian cell
Academic Press, 1993: ISBN-13: 9780122653308, 2010