The researchers at La Jolla Bioengineering Institute are responsible
for hundreds of leading research articles, various book chapters and
patents. Here you will find a list of selected publications for
each of LJBI's Principal Investigators.
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Frangos, J.A., S.G. Eskin, L.V,
McIntire and C.L. Ives: "Flow Effects on
Prostacyclin Production by Cultured Human Endothelial
Cells." Science, 227:1477-1479, 1985. [Full
Text]
Eskin, S.G., C.L. Ives, J.A. Frangos and L.V, McIntire: "Cultured Endothelium: The
Response to Flow." American Society of Artificial Internal
Organs Journal, 8:109-112, 1985.
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Frangos, JA., L.V. McIntire,
S.G. Eskin and E.R. Hall: "Effect of Hemodynamic Shear
on Arachidonic Acid Metabolism of Vascular Endothelium."
In: Cerebral Ischemia and Hemorheology, 280-289, A.
Hartman ed., Springer-Verlag, 1987.
McIntire, LV., J.A. Frangos,
B.G. Rhee, S.G. Eskin and E.R. Hall: "The Effect of
Fluid Mechanical Stress on Cellular Arachidonic
Metabolism." Annuals of New York Academy of Science,
516:513-524, 1988.
Frangos, J.A., L.V. McIntire
and S.G. Eskin: "Shear Stress Induced Stimulation of
Mammalian Cell Metabolism." Biotechnology and
Bioengineering, 32:1053-1060, 1988. [Full
Text]
Frangos, J.A., J.L. Moake
and L.V. McIntire: "Cryosupernatant Regulates
Accumulation of Unusually Large vWF Multimers from Endothelial
Cells." American Journal of Physiology, 256:H1635-H1644,
1989. [Full
Text]
Bhagyalakshmi, A., and J.A.
Frangos: "Mechanism of Shear-Induced Prostacyclin
Production in Endothelial Cells." Biochemical Biophysical
Research Communication, 158:31-37, 1989.
Gupte, A., and J.A. Frangos:
"Effects of Flow on the Synthesis and Release of
Fibronectin by Endothelial Cells." In Vitro Cellular
Development Biology, 26:57-60, 1990.
Reich, K.M., C.V. Gay and
J.A. Frangos: "Fluid Shear Stress as a Mediator of
Osteoblast Cyclic Adenosine Monophosphate Production."
Journal of Cellular Physiology, 143:100-103, 1990.
Hsieh, H.J., N.Q. Li and J.A.
Frangos: "Shear Stress Increases Endothelial
Platelet-Derived Growth Factor mRNA Levels." American
Journal of Physiology, 260:H642-H646, 1991. [Full
Text]
Jarvis, P., J.M. Tarbell and
J.A. Frangos: "An In Vitro Evaluation of an Artificial
Heart." American Society of Artifical Internal Organs
Transactions, 37:27-32, 1991.
Reich, K.M., and J.A. Frangos:
"Effect of Flow on Prostaglandin E2 and Inositol
Triphosphate Levels in Osteoblasts." American Journal of
Physiology, 261:C428-C432, 1991. [Full
Text]
Hsieh, H.J., N.Q. Li and J.A.
Frangos: "Shear-Induced Platelet-Derived Growth Factor
Gene Expression in Human Endothelial Cells is Mediated by
Protein Kinase-C." J Cellular Physiology, 150:552-558,
1991.
Berthiaume, F., and J.A.
Frangos: "Flow-Induced Prostacyclin Production is
Mediated by a Pertussis Toxin-Sensitive G-Protein." FEBS
Letters, 308:277-279, 1992. [Full
Text]
Bhagyalakshmi, A., F. Berthiaume and J.A. Frangos: "Fluid Shear Stress
Stimulates Membrane Phospholipid Metabolism in Cultured Human
Endothelial Cells." Journal of Vascular Research,
29:443-449, 1992.
Hsieh, H.J., N.Q. Li and J.A. Frangos: "Pulsatile and Steady Flow Induces c-fos
Expression in Human Endothelial Cells." Journal of
Cellular Physiology, 154:143-151, 1993.
Reich, K.M., and J.A. Frangos:
"Protein Kinase C Mediates Flow-Induced Prostaglandin E2
Production in Osteoblasts." Calcified Tissue
International, 52:62-66, 1993.
Gooch K.J., and J.A. Frangos:
"Shear Sensitivity in Animal Cell Culture." Current
Opinion in Biotechnology, 4:193-196, 1993.
Lamson, T.C., G. Rosenberg,
D.V. Geselowitz, S. Deutsch, D.R. Stinebring, J.A. Frangos
and J.M. Tarbell: "Relative Blood Damage in the Three
Phases of a Prosthetic Heart Valve Flow Cycle." American
Society of Artifical Internal Organs Journal, 39:626-633,
1993.
Berthiaume, F., and J.A.
Frangos: "Effects of Flow on Anchorage-Dependent
Mammalian Cells-Secreted Products." Physical Forces and
The Mammalian Cell. J.A. Frangos, ed., Academic Press, Inc.,
1993.
Kuchan, M.J., and J.A.
Frangos: "Shear Stress Regulates Endothelin-1 Release Via
Protein Kinase C and cGMP in Cultured Endothelial Cells."
American Journal Physiology, 264:H150-H156, 1993. [Full
Text]
Berthiaume, F., and J.A.
Frangos: "Flow Effects on Endothelial Cell Signal
Transduction, Function and Mediator Release." in Flow
Dependent Regulation of Vascular Function. ed. J. Bevan, G.
Kaley, and G. Rubanyi, Oxford University Press, 1994
Hillsley, M.V., and J.A.
Frangos: "Bone Tissue Engineering: The Role of
Interstitial Fluid Flow." Biotechnology and
Bioengineering, 43:573-581, 1994. [Full
Text]
Garrison, L.A., J.A. Frangos,
D.B. Geselowitz, T.C. Lamson and J.M. Tarbell: "New Mock
Circulatory Loop and its Application to the Study of Chemical
Additive and Aortic Pressure Effects on Hemolysis in the Penn
State Electric Ventricular Assist Device." Artificial
Organs, 17:397-407, 1994.
Gudi, S.R.P., and J.A.
Frangos: "Mechanical Signal Transduction and
G-Proteins." Cell Mechanics and Cellular Engineering, ed.
V. Mow, Springer-Verlag (New York), 1994
Berthiaume, F., and J.A.
Frangos: "Fluid Flow Increases Membrane Permeability to
Merocyanine 540 in Human Endothelial Cells." Biochimica
Biophysica Acta, 1191:209-218, 1994.[Full
Text]
Kuchan, M.J., and J.A.
Frangos: "Role of Calcium and Calmodulin in Flow-Induced
Nitric Oxide Production in Endothelial Cells." American
Journal of Physiology, 266:C628-C636, 1994. [Full
Text]
Kuchan, M.J., H. Jo and J.A.
Frangos: "Role of G proteins in Shear Stress-Mediated
Nitric Oxide Production by Endothelial Cells." American
Journal of Physiology, 267:C753-C758, 1994. [Full
Text]
Hsieh, H.J., N.Q. Li and J.A.
Frangos: "Shear Stress-Induced Gene Expression in Human
Endothelial Cells." Tissue Engineering, ed. E. Bell, Birkhauser Publishers,
155-166, 1994.
Sill, H.W., Y.S. Chang, J.R.
Artman, J.A. Frangos, T.M. Hollis and J.M. Tarbell.
"Shear Stress Increases Hydraulic Conductivity in
Cultured Endothelial Monolayers." Am. J. Phys.,
268:H535-H543, 1995. [Full
Text]
Nulend, J.K., A. van der Plas,
C. Semeins, N.E. Ajbui, J. A. Frangos, P.J. Nijweide and E.H.
Burger: "Sensitivity of Osteocytes to Biomechanical
Stress In Vitro." FASEB Journal, 9:441-445, 1995. [Full
Text]
Botella, J.R., R.N. Arteca
and J.A. Frangos: "A Mechanical Strain-Induced
1-Aminocyclopropane-1-Carboxylic Acid Synthase Gene."
Proceedings of the National Academy of Science, USA, 92:1595-1598, 1995. [Full
Text]
Rossitti, S., J.A. Frangos, P.R.
Girard and J. Bevan: "Regulation of Vascular Tone"
Canadian Journal of Physiology Pharmacology, 73:544-550, 1995.
Gooch, K.J., and J.A. Frangos:
"Flow-and Bradykinin-Induced Nitric Oxide Production by
Endothelial Cells is Independent of Membrane Potential."
American Journal of Physiology, 270:C546-C551, 1996. [Full
Text]
Hillsley, M.V., and J.A.
Frangos: "Osteoblast Hydraulic Conductivity is Regulated
by Calcitonin and Parathyroid Hormone." Journal of Bone
and Mineral Research, 11:114-124, 1996.
Johnson, D.L., T. N.McAllister and J.A. Frangos: "Fluid Flow Stimulates
Rapid and Continuous Release of Nitric Oxide in Osteoblasts",
American Journal of Physiology, 271:E205-E208, 1996. [Full
Text]
Frangos, J.A., T.Y. Huang
and C.B. Clark: "Steady Shear and Step Changes in Shear
Stimulate Endothelium Via Independent Mechanisms -
Superposition of Transient and Sustained Nitric Oxide
Production." Bioch. Biophys. Res. Comm, 270:C546-C551,
1996. [Full Text]
Alshihabi, S. N., Y.S. Chang, J.A.
Frangos and J.M. Tarbell: "Shear Stress-Induced
Release of PGE2 and PGI2 by Vascular Smooth Muscle
Cells." Bioch. Biophys. Res. Comm, 224:808-814, 1996. [Full
Text]
Gudi, S.R., C.B. Clark and
J.A. Frangos: "Fluid Flow Rapidly Activates G Proteins in
Human Endothelial Cells." Circulation Research, 79:834-9, 1996.
Hillsley, M.V., and J.A.
Frangos: "Alkaline phosphatase in osteoblasts is
down-regulated by pulsatile fluid flow." Calcif Tissue
Int 60:48-53, 1997. [Full
Text]
Reich, K.M., T.N. McAllister,
S.R.P. Gudi and J.A. Frangos: "Activation of G proteins
Mediates Flow-induced Prostaglandin E2 Production in
Osteoblasts.", Endocrinology, 138:1014-1018, 1997. [Full
Text]
Gooch, K.J., C.A. Dangler
and J.A. Frangos: "Exogenous, Basal, and Flow-Induced
Nitric Oxide Production and Endothelial Cell
Proliferation.", Journal of Cellular
Physiology,171:252-258, 1997. [Full
Text]
Knudsen, H.L., and J.A.
Frangos: "Role of the Cytoskeleton in Shear
Stress-Induced Endothelial Nitric Oxide Production.",
American Journal of Physiology, 273:H347-H355, 1997. [Full
Text]
Shah V., F.G. Haddad, G.
Garcia-Cardena, J.A. Frangos, A. Mennone, R.J. Groszmann and W.C.
Sessa: "Liver sinusoidal endothelial cells are
responsible for nitric oxide modulation of resistance in the
hepatic sinusoids". Journal of Clinical Investigation,
100:2923-2930, 1997. [Full
Text]
Gudi, S.R.P., J.P. Nolan and
J.A. Frangos: "Modulation of GTPase Activity of
Reconstituted G Proteins by Fluid Shear Stress and
Phospholipid Composition", Proc. Natl. Acad. Sci. USA.,
95:2515-2519, 1998. [Full
Text]
Gudi, S.R.P., A.A. Lee, C.B. Clark and J.A. Frangos: "Equibiaxial Strain Stimulates
Early Activation of G Proteins in Cardiac Fibroblasts: The
Role of Strain and Strain Rate in Mechanical Signaling",
American Journal of Physiology, 274:C1424-C1428, 1998. [Full
Text]
Ishizaka,H., S.R. Gudi, J.A. Frangos and L. Kuo: "Coronary Arteriolar Dilation to
Acidosis: Role of ATP-sensitive Potassium Channels and
Pertussis Toxin-Sensitive G Proteins", Circulation,
99:558-563, 1999. [Full Text]
Bergula, A., W. Huang, and J.A.
Frangos: "Femoral Vein Ligation Increases Bone Mass in the
Hindlimb Suspended Rat", Bone 171-177, 1999. [Full
Text]
McAllister, T.N., and J.A.
Frangos: "Nitric Oxide and Mechanical Factors: Fluid
Shear Stress", in Nitric Oxide in Arthritis and
Osteoporosis, ed. M. Hukkanen, J. Polak, and S.P.F. Hughes,
Cambridge University Press, 141-150, 1998.
Bao, X., C. Lu and J.A.
Frangos: "Temporal Gradient in Shear but Not Steady Shear
Stress Induces PDGF-A and MCP-1 Expression in Endothelial
Cells: Role of NO, NFkB, and egr-1", Arteriosclerosis,
Thrombosis, and Vascular Biology, 19:996-1003, 1999. [Full
Text]
McAllister, T.N., and J.A.
Frangos: "Steady and Transient Fluid Shear Stress
Stimulate NO Release in Osteoblasts Through Distinct
Biochemical Pathways", J. Bone Mineral Res,. 14:930-936,
1999. [Full Text]
Suzuki, R., and J.A. Frangos:
"Inhibition of Inflammatory Species by Titanium
Surfaces". Clinical Orthopaedics and Related Research,
372:280-289, 2000. [Full
Text]
Chang, Y., J.A. Yaccino, S.
Laksminarayanan, J.A. Frangos and J.M. Tarbell:
"Shear-Induced Increase in Hydraulic Conductivity in
Endothelial Cells is Mediated by a Nitric Oxide-Dependent
Mechanism", Arteriosclerosis, Thrombosis, and Vascular
Biology, 20:35-42, 2000. [Full
Text]
Haidekker, M., N. L'Heureux and J.A. Frangos: "Fluid Shear Stress Increases Membrane
Fluidity In Endothelial Cells: A Study with DCVJ
Fluorescence", Am J Physiol, 278: H1401-H1406, 2000. [Full
Text]
Bao, X, C.B. Clark and J.A.
Frangos: "Temporal Gradient in Shear-induced Signaling
Pathway-Involvement of MAP Kinase, c-fos and
Connexin-43", Am J Physiol, 278: H1598-H1605, 2000. [Full
Text]
McAllister, T.N., T. Du and J.A. Frangos: "Fluid Shear Stress Stimulates
Prostaglandin and Nitric Oxide Release in Bone Marrow-Drived
Preosteoclast-like Cells", Biochem Biophys Res Commun
270:643-648, 2000. [Full
Text]
Haidekker, M.A., and J.A.
Frangos: "A fluorescent molecular rotor for the study of
membrane fluidity in endothelial cells under fluid shear
stress", In: Farkas, D.L., and R.C. Leif (eds). Optical
diagnostics of living cells III, Proc SPIE 3291:101-112,
2000. [Full
Text]
White, C.R., M.A. Haidekker, X. Bao and J.A.
Frangos. "Temporal gradients in shear stress, but not
spatial gradients, stimulate endothelial cell
proliferation", Circulation 103: 2508-2513, 2001. [Full
Text]
Haidekker, M.A., C.R. White
and J.A. Frangos, "Analysis of temporal shear stress
gradients during the onset phase of flow over a
backward-facing step", Journal of Biomechanical
Engineering 123:455-463, 2001 [Full
Text]
Haidekker, M.A., T. Ling, M.
Anglo, H.Y. Stevens, J.A. Frangos and E.A. Theodorakis,
"New fluorescent probes for the measurement of cell
membrane viscosity", Chemistry and Biology 8:123-131,
2001. [Full Text]
Bao, X.P., C. Lu and J.A.
Frangos, "Mechanism of temporal gradients in
shear-induced ERK1/2 activation and proliferation in
endothelial cells", Am J Physiol 281:H22-H29, 2001. [Full
Text]
Clark, C.B., T.J. Burkholder
and J.A. Frangos, "Uniaxial strain system to investigate
strain rate regulation in vitro", Rev Scient Instr 72:2415-2422, 2001. [Full Text]
Haidekker, M.A., A.G. Tsai, T. Brady,
H. Y. Stevens, J. A. Frangos, E.A. Theodorakis and M.
Intaglietta. "A novel approach to blood plasma viscosity
measurement using fluorescent molecular rotors" Am. J
Physiol Heart Circ Physiol 282:H1609-H1614, 2002. [Full Text]
Mallipattu, SK, M.A.
Haidekker, P. Von Dassow, M. I. Latz and J. A. Frangos.
"Evidence for shear-induced increase in membrane fluidity
in the dinoflagellate Lingulodinium polyedrum", J Comp
Physiol A 188:409-416, 2002. [Full
Text]
Jiang, G.L., C.R. White, H.Y.Stevens and J.A. Frangos. "Temporal Gradients in
Shear Stimulate the Proliferation of Osteoblastic Cells
Through ERK1/2 and Retinoblastoma Protein", Am. J.
Physiol Endo 283:E383–E389, 2002. [Full
Text]
Haidekker, M.A., T. Brady, K. Wen,
C. Okada, H. Y. Stevens, J. M. Snell, J.A. Frangos and E. A.
Theodorakis "Phospholipid-bound Molecular Rotors:
Synthesis and Characterization", Bioorg Med Chem 10:3627-3636, 2002. [Full
Text]
Frangos, J. A. "The mechanism of mechanosensing by bone." J Biomech 35(3):
387-389, 2002.
Clark, C.B., N.L. McKnight and J.A. Frangos. "Strain and strain rate activation of G
proteins in human endothelial cells" Biochemical
and Biophysical Research Comm. 299:258-262, 2002. [Full
Text]
Suzuki, R., J. Muyco, J.
McKittrick and J.A. Frangos. "Reactive Oxygen Species Inhibited
by Titanium Oxide Coatings" Journal
of Biomedical Materials Research, 66A:396–402, 2003. [Full
Text]
Chen, A.K, M.I. Latz and J.A. Frangos. "The Use of Dinoflagellate Bioluminescence
to Characterize Cell Stimulation in Bioreactors"
Biotechnology and Bioengineering 83:93-103, 2003. [Full
Text]
McKnight, N., and J.A.
Frangos. "Strain Rate Mechanotransduction in Aligned
Human Vascular Smooth Muscle Cells" Annals of
Biomedical Engineering. 31:239-249, 2003. [Full
Text]
Gudi, S.R., I. Huvar, N.L. McKnight,
C.R. White, N. Duserre, G.R. Boss and J.A Frangos. "Rapid Activation of Ras by Fluid Flow
is Mediated by Gaq
and Gbg Subunits
of Heterotrimeric G Proteins in Human Endothelial Cells",
Arterioscler Thromb Vasc Biol. 23:994-1000, 2003. [Full
Text]
White, C.R., N. Dusserre and J.A. Frangos.
"Steady and Unsteady Fluid Shear
Control of Inflammation." Molecular
Basis of Microcirculatory Disorders. ed Schmid-Schoenbein, G.W., Granger,
N.D. Springer Verlag, 141-160, 2003. [Full
Text]
Stevens, H.Y., and J.A.
Frangos. "Bone Cell Responses to Fluid Flow." Methods in
Molecular Medicine, Bone Research Protocols. ed
Helfrich, M.H., Ralston, S.H., 80:381-398, 2003. [Full
Text]
Battaglia, A., K. Pak,
D. Brors, D. Bodmer, J.A. Frangos and A.F. Ryan. " Involvement
of RAS activation in toxic hair cell damage of the mammalian
cochlea", Neuroscience
122: 1025–1035, 2003. [Full
Text]
Clark, C.B., N.L. McKnight and J.A.
Frangos. "Stretch activation of GTP-binding proteins in C2C12
myoblasts." Experimental Cell Research 292:265–273, 2004. [Full
Text]
Haidekker, M.A., H.Y. Stevens and J.A.
Frangos, "Cell Membrane Fluidity Changes and Membrane
Undulations Observed using a Laser Scattering Technique." Annals
of Biomedical Engineering, Vol. 32:531–536, 2004. [Full
Text]
Bergula, A., M.A. Haidekker, H.Y. Stevens,
W. Huang, J.A. Frangos. "Venous ligation-mediated bone adaptation is
NOS 3 dependent." Bone 34:562-569, 2004. [Full
Text].
Haidekker, M. A., H.Y. Stevens and
J.A. Frangos, "Computerized methods for X-ray-based small bone
densitometry." Computer Methods and Programs in Biomedicine
73:35-42, 2004. [Full
Text]
White, C.R., M.A. Haidekker, H.Y.
Stevens and J.A. Frangos. "Extracellular
signal-regulated kinase activation and endothelin-1 production in
human endothelial cells exposed to vibration." J Physiol 555.2:565–572, 2004. [Full
Text]
Cabrales,
P., A.G. Tsai,
J.A. Frangos, J.C.
Briceño and M. Intaglietta. “Oxygen delivery and
consumption in the microcirculation after extreme hemodilution with
perfluorocarbons.” Am
J Physiol Heart Circ Physiol 287:H320–H330, 2004. [Full
Text]
Dusserre,
N., N. L’Heureux, K.S. Bell, H.Y. Stevens, J. Yeh, L.A. Otte, L. Loufrani
and J.A. Frangos, "PECAM-1 Interacts with Nitric Oxide Synthase in Human
Endothelial Cells." Arterioscler Thromb
Vasc Biol. 24:1796-1802, 2004 [Full
Text].
Bagi,
Z., J.A Frangos, J. Yeh, C.R. White, G. Kaley and A. Koller. "PECAM-1
Mediates NO-Dependent Dilation of Arterioles to High Temporal
Gradients of Shear Stress." Arterioscler Thromb
Vasc Biol. 25:1590-1595, 2005. [Full
Text]
White, C.R., H.Y. Stevens, , M.A. Haidekker
and J.A. Frangos. "Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2
activation in human endothelial cells." Am J Physiol Heart Circ Physiol 289:H2350–H2355,
2005. [FullText]
Cabrales, P., A.G. Tsai, J.A. Frangos
and M. Intaglietta. "Role of endothelial nitric oxide in microvascular oxygen delivery and consumption." Free Radic Biol Med
39:1229-1237, 2005 [Full
Text]
Gramaglia, I., H. Sahlin, J.P. Nolan,
J. A. Frangos, M. Intaglietta and H. C. van der Heyde. "Cell- Rather Than Antibody-Mediated Immunity Leads to the Development of Profound Thrombocytopenia during Experimental Plasmodium berghei Malaria." J Immunol
175: 7699-7707, 2005. [Full Text]
Martini, J., B. Carpentier, A.C.
Negrete, J.A. Frangos and M. Intaglietta. "Paradoxical hypotension following increased hematocrit and blood viscosity." Am J Physiol Heart Circ Physiol
289:H2136-H2143, 2005. [Full
Text]
Sobolewski, P.I., I. Gramaglia, J.A. Frangos and M.
Intaglietta and H.C. van der Heyde. "Plasmodium berghei resists killing by reactive oxygen species." Infect Immun
73:
6704-6710, 2005. [Full
Text]
Sobolewski, P. I., I. Gramaglia, J. A.
Frangos, M. Intaglietta and H. C. van der Heyde. "Hemoglobin serves to protect Plasmodium parasites from nitric oxide and reactive oxygen species." J Investig Med
53:246-52, 2005.
Sobolewski, P. I., I. Gramaglia, J.A.
Frangos, M. Intaglietta and H. C. van der Heyde. "Nitric oxide bioavailability in malaria." Trends Parasitol
21:415-422, 2005. [Full
Text]
Tsai, A. G., C. Acero, P.R. Nance, P.
Cabrales, J. A. Frangos, D.G. Buerk and M. Intaglietta. "Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion." Am J Physiol Heart Circ Physiol
288: H1730-H1739, 2005. [Full
Text]
White, C.R., M. W. Hamade, K. Siami, M. M.
Chang, A. Mangalwadi, J.A. Frangos and W.J. Pearce. "Maturation enhances fluid shear-induced activation of eNOS in perfused ovine carotid arteries." Am J Physiol Heart Circ Physiol
289:H2220-H2227, 2005. [Full
Text]
Stevens, H.Y., D.R. Meays, J. Yeh,
L.M. Bjursten and J.A. Frangos. "COX-2 is necessary for venous ligation-mediated bone
adaptation in mice" Bone 38:93-104, 2006 . [Full
Text]
Sahlin, H., R. Contreras, D. Gaskill,
L.M. Bjursten and J.A. Frangos. "Anti-inflammatory properties of micropatterned titanium
coatings" J Biomed Mater Res A. 77:43-9, 2006. [Full
Text]
Stevens, H.Y., D.R. Meays and J.A. Frangos.
"Pressure gradients and transport in the murine femur upon
hindlimb suspension" Bone 39:565-572, 2006. [Full
Text]
Wang Y, B.S. Maciejewski, N. Lee, O. Silbert,
N.L. McKnight, J.A. Frangos, and J. Sanchez-Esteban. "Strain-induced
fetal type II epithelial cell differentiation is mediated via
cAMP-PKA-dependent signaling pathway" Am
J Physiol Lung Cell Mol Physiol. 291: L820-L827, 2006. [Full
Text]
Contreras,
R., H. Sahlin, J.A. Frangos. "Titanate biomaterials with
enhanced antiinflammatory properties" J Biomed Mater Res A.
0:480-5 2006, 2007. [Full
Text]
Zhang,
Y.L., J.A. Frangos, M. Chachisvilis. "Laurdan fluorescence
senses mechanical strain in the lipid bilayer membrane" Biochem
Biophys Res Commun. 347:838-841, 2006 . [Full
Text]
Chachisvilis M, Y.L. Zhang, and J.A. Frangos. "G protein-coupled receptors sense fluid shear stress in endothelial cells." Proc Natl Acad Sci U S A.
103: 15463-15468, 2006. [Full
Text]
Gramaglia
I, P Sobolewski, D Meays, R Contreras, JP Nolan, J.A. Frangos, M
Intaglietta , HC van der Heyde, “Low nitric oxide bioavailability
contributes to the genesis of experimental cerebral malaria.” Nature
Medicine 12: 1417-1422, 2006. [Full
Text].
Chen
AK, MI Latz, P
Sobolewski, and J.A.
Frangos. "Evidence
for the Role of G-Proteins in Flow Stimulation of Dinoflagellate
Bioluminescence." Am J Physiol Regul Integr Comp Physiol 292:
R2020-R2027,
2007. [Full
Text].
White
CR and J.A. Frangos, "The shear stress of it all: the cell
membrane and mechanochemical transduction." Philos Trans R Soc
Lond B Biol Sci. 362(1484):1459-67, 2007. [Full
Text].
Book
Frangos, J.A., Editor:
Physical Forces and the Mammalian Cell. Academic Press, 1993.
Patents
Patent: McAllister,T.N., M.
Latz, and J.A. Frangos: "Luminescent Flow Additive for
Flow Visualization", U.S. Patent #5730321, 1998.
Patent: Theodorakis, Emmanuel
A., Haidekker, Mark A., and Frangos, John A. "Molecular
rotor derivatives and methods of use" PCT Int. Appl.
pending (2002)
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